Clinical Research Directory

Inclusion Criteria: * Eastern Cooperative Oncology Group (ECOG) performance status ≤1. * Subjects with advanced or metastatic solid tumors (except thymic tumors), which have progressed after all standard therapies, or no further standard therapies exists. * At least 1 measurable lesion per Response Evaluation Criteria in Solid Tumors version 1.1 (RECIST 1.1). * Adequate organ function. * Woman of childbearing potential must agree to use 2 methods of acceptable contraception from screening until 6 months after the last dose of study drug. * Male subjects who are sexually active with a female partner of childbearing potential must agree to use a barrier contraception. Exclusion Criteria: * Subjects within washout period of other anti-tumor therapies. . * History of prior malignancy other than the cancer under treatment in the study. * Major trauma or major surgery within 4 weeks before the first dose of study drug. * Serious nonhealing wound, ulcer, or bone fracture. * History of significant immune-mediated AE. * Central nervous system (CNS) disease involvement. * Any evidence of underlying severe liver dysfunction. * Prior organ allograft transplantations or allogeneic bone marrow, cord blood or peripheral blood stem cell transplantation. * Clinically significant cardiac disease with insufficient cardiac function. * Evidence of active uncontrolled viral, bacterial, or systemic fungal infection. * Known positive test result for human immunodeficiency virus (HIV) or acquired immune deficiency syndrome (AIDS). * Infection of hepatitis B virus (HBV), or hepatitis C virus (HCV) (unless the disease is clinically controlled) . * History or risk of autoimmune disease. * Subjects with active severe lung infection or with a history of interstitial lung diseases, noninfectious pneumonitis, active pulmonary tuberculosis, or evidence of active pneumonitis. Clinically significant and unmanageable ascites defined as requiring constant therapeutic paracentesis. * Any serious underlying issue that would limit compliance with study requirements, impair the ability of the subject to understand informed consent. * Known hypersensitivity, allergies, or intolerance to immunoglobulins or to any excipient contained in ADG206. * Pregnant, lactating, or breastfeeding.