Clinical Research Directory

Inclusion Criteria: 1. Age≥18 years; 2. Acute basilar artery occlusion confirmed by CTA/MRA/DSA; 3. Last known well to puncture time≤24 hours; 4. pc-ASPECTS score≥6 points; 5. Baseline NIHSS score≥10 points; 6. Consent to endovascular treatment; 7. Informed consent signed. Clinical Exclusion Criteria: 1. Baseline mRS≥3 points; 2. Known or suspected severe basilar artery stenosis (\>70%) or chronic occlusion based on history, imaging, or clinical manifestations; 3. Refractory hypertension that is difficult to be controlled by drugs (defined as persistent systolic blood pressure \>185 mmHg or diastolic blood pressure \>110 mmHg) 4. Genetic or acquired hemorrhagic tendency, coagulation factor deficiency or on anticoagulant therapy and International Normalized Ratio (INR) \> 3.0; 5. Laboratory tests: baseline blood glucose \<50mg/dl (2.8mmol/L) or \>400mg/dl (22.2mmol/L); Baseline platelet count \<50×109/L; 6. Known severe allergy (more severe than skin rash) to contrast agents uncontrolled by medications; 7. Females who are pregnant, or those of childbearing, potential with positive urine or serum beta Human Chorionic Gonadotropin test; 8. Other circumstances that the investigator considers inappropriate for participation in the trial or that may pose significant risks to patients (such as inability to understand and/or follow the study procedures and/or follow up due to mental disorders, cognitive or emotional disorders). Imaging Exclusion Criteria: 1. CT or MR evidence of acute intracranial hemorrhage (the presence of microbleeds on MRI is allowed); 2. Midline shift or herniation, mass effect with effacement of the ventricles; 3. Complete cerebellar infarct on CT or MRI with significant mass effect and compression of the 4-th ventricle; 4. Complete bilateral thalamic infarction on CT or MRI; 5. Inability to endovascular treatment due to Excessive tortuosity, variation, or dissection of the artery; 6. Subjects with occlusions in both intracranial vertebral arteries; 7. Subjects with occlusions in both anterior and posterior circulation; 8. Evidence of intracranial tumor (except small meningioma).