Clinical Research Directory

Inclusion Criteria: * Patient 18 years of age or older * Patient with Modic I lateralized disc disease seen on an MRI less than 6 months old. * Chronic medial or lateralized (same side as MODIC 1) low back pain for at least 3 months with a mean pain intensity ≥ 40/100 mm on a VAS. * Effective contraception for women of childbearing age, at least 6 months after injection (surgical sterilisation, approved hormonal contraceptives, barrier methods, intrauterine intrauterine device) Exclusion Criteria: * Patient with MODIC 1 in both underlying and overlying vertebral spaces. * Patient with an inflammatory signal abnormality of the vertebral body plateau related to non-mechanical pathology (e.g. spondyloarthritis). * Patients with a history of lumbar spine surgery. * Patient with suspected spondylodiscitis or other infection. * Patients on anticoagulant or antiaggregant therapy, or with a coagulation disorder. * Patients with an allergy to iodine or to any of the components of Xylocaine. * Patients with an allergy to prednisolone or to any component of Hydrocortancyl® or Dexamethasone®.. * Patient with severe uncontrolled disease (i.e. cardiac gastrointestinal, neurological, endocrine, autoimmune) that limits patient safety (as determined by the safety (as judged by the investigator). * Prior to the treatment visit : * current and recent morphine use (\< 1 month) * recent systemic or local corticosteroid therapy (\< 1 month). * Patient with sphincter disturbances indicative of cauda equina syndrome. * Psychotic state not controlled by treatment * Pregnancy (βHCG positive), breastfeeding * Vulnerable patient protected by law * Patient under guardianship or curatorship * Patient participating in an interventional study * Patient unable to read and/or write