Clinical Research Directory

Inclusion Criteria: * Children (age 6-17) or young adults (age 18-39). * Known or suspected UC or IBDU \[there will be 2 control group: non-IBD (undergoing colonoscopy but found not to have IBD; and healthy (no GI symptoms, so not required to have colonoscopy; could be family members)\] * For UC: Remission-mild-moderate disease: Mayo score \<10 * Clinical indication for sedated colonoscopy * Disease location: E2-E4 * Stable treatment (not on steroids; biologics or immunomodulator not changed in last month) * High likelihood that patients will be able to collect all samples and provide all data Exclusion Criteria: * Use of antibiotics for a week or more over the last 3 months * Use of probiotics or prebiotics at pharmacological doses (adding fibre sources to food or probiotics in yogurt, for example, are allowed) * History of abdominal surgery, including appendectomy * Documented enteric infection during the 3 months prior to endoscopy * Presence of non-IBD bowel conditions (e.g., celiac), anatomical or mucosal abnormalities, motility disorder * Presence of a systemic disease requiring treatment (cancer, ischemic heart disease, kidney failure, etc) * Proctitis (E1) * Systemic steroids (above 10 mg/day of Prednisone) * Topical therapy within 1 week of endoscopy * Recent change in IBD treatment (started biologics or IM over the last month) * Pregnancy or planning to become pregnant during the study * Inability to understand or sign the consent