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Inhaled Nitric Oxide for Microvascular Dysfunction in Traumatic Brain Injury
Sponsor: University of Pennsylvania
Summary
Traumatic brain injury (TBI) causes acute deficits in cerebral perfusion which may lead to secondary injury and worse outcomes. Inhaled nitric oxide (iNO) is a vasodilator that increases cerebral blood flow and is clinically used for hypoxic respiratory failure in neonates and adults. The investigators will perform a randomized controlled trial of iNO treatment in TBI patients acutely after injury. The investigators will then assess perfusion changes with optic neuromonitoring, blood biomarkers, and 6 month clinical outcomes.
Key Details
Gender
All
Age Range
18 Years - 75 Years
Study Type
INTERVENTIONAL
Enrollment
38
Start Date
2025-04-06
Completion Date
2028-03-28
Last Updated
2025-06-03
Healthy Volunteers
No
Conditions
Interventions
inhaled nitric oxide
iNO will be provided by ventilator or nasal cannula for 4 hours each day.
Locations (1)
Penn Presbyterian Medical Center
Philadelphia, Pennsylvania, United States