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Mindfulness-Based fMRI Neurofeedback for Depression
Sponsor: Columbia University
Summary
In the United States, adolescents experience alarmingly high rates of major depression, and gold-standard treatments are only effective for approximately half of patients. Rumination may be a promising treatment target, as it is well-characterized at the neural level and contributes to depression onset, maintenance, and recurrence as well as predicts treatment non-response. Accordingly, the proposed research will investigate whether an innovative mindfulness-based real-time functional magnetic resonance imaging (fMRI) neurofeedback intervention successfully elicits change in the brain circuit underlying rumination to improve clinical outcomes among depressed adolescents.
Official title: Targeting Adolescent Depression Symptoms Using Network-based Real-time fMRI Neurofeedback and Mindfulness Meditation (NIMH); Mindfulness-Based Real-Time fMRI Neurofeedback for Depression (IRB)
Key Details
Gender
All
Age Range
13 Years - 18 Years
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2024-04-10
Completion Date
2026-06-30
Last Updated
2025-04-24
Healthy Volunteers
No
Conditions
Interventions
Mindfulness + fMRI Neurofeedback
Prior to neurofeedback, participants will receive 45 minutes of mindfulness training. Participants will then receive mindfulness-based fMRI neurofeedback targeting the default mode network and frontoparietal control network.
Locations (2)
Northeastern University
Boston, Massachusetts, United States
Columbia University Irving Medical Center
New York, New York, United States