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New Strategies for Assessment of the Persistence of Viable Bacilli in Latent and Active Tuberculosis
Sponsor: Region Skane
Summary
Current diagnostic tools such as interferon gamma release assay (IGRA) and purified protein derivative (PPD) can not distinguish patients with latent tuberculosis infection (LTBI) and persistence of live mycobacteria. This inability to rule out living mycobacteria in patients investigated for LTBI leads to unnecessary and potentially harmful treatment regimes all around the globe. The goal of this observational study is to identify candidate biomarkers for viable bacilli in latent tuberculosis in order to decrease the use of unnecessary and ineffective antibiotic treatment.
Key Details
Gender
All
Age Range
15 Years - 100 Years
Study Type
OBSERVATIONAL
Enrollment
130
Start Date
2021-12-21
Completion Date
2024-12
Last Updated
2024-06-18
Healthy Volunteers
No
Locations (1)
Skåne University Hospital
Malmo, Skåne County, Sweden