Clinical Research Directory

Inclusion Criteria: * Signed consent obtained before any study-related activities (study-related activities are any procedure related to recording of data according to the protocol). * Male, greater than or equal to 18 years of age at the time of signing informed consent, diagnosed with severe (FVIII activity below 1%) or moderate congenital haemophilia A (FVIII activity 1-5%). * The decision to initiate treatment with commercially available Esperoct has been made by the patient and the treating physician before and independently from the decision to include the patient in this study. * Switched, within two months prior to enrolment, OR planned to switch, within one month post enrolment, to prophylaxis treatment with Esperoct from previous therapy; the decision to initiate treatment with Esperoct must be made prior to and independently from the decision to enrol in the study. * Must have baseline data (HJHS, target joints, and medical history) collected in routine clinical practice within two months prior or up to one month post switch to Esperoct therapy. Exclusion Criteria: * Previous participation in this study. Participation is defined as having given informed consent in this study. * Previous terminated treatment regimen with Esperoct prophylaxis. * Current or previously terminated treatment regimen with Esperoct on-demand. * Mental incapacity, unwillingness or language barriers precluding adequate understanding or cooperation. * Previous participation in a clinical trial within the 30 days prior to switching to Esperoct.