Clinical Research Directory

Inclusion Criteria: * Septic patients with acute gastrointestinal injury grade II or III; * Age over 18 years; * Expected to stay in the ICU for at least 3 days or longer; Exclusion Criteria: * Mean arterial pressure less than 65 mmHg after fluid resuscitation, or requirement for an intravenous norepinephrine dose of greater than 0.5 µg/kg/min to maintain a normal mean arterial pressure; * Heart rates less than 50 beats/min, or concomitant with moderate-to-severe atrioventricular block without a pacemaker; * Contraindications for erector spinae plane blocks, including infection of the puncture site, spinal diseases or immobilization; * Primary gastrointestinal disorders requiring a surgical procedure, such as mechanical intestinal obstruction, massive gastrointestinal hemorrhage, and gastrointestinal perforation; * Gastrointestinal operation within one week before enrollment; * Neuromuscular disorders; * Coagulation abnormalities：activated prothrombin time or prothrombin time is prolonged with 2 folds, or platelet count less than 50×109/L; * End-stage malignant tumor or cachexia; * History of allergy to amide anesthetics; * Known pregnancy;