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Efficacy and Safety of Tozorakimab in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
Sponsor: AstraZeneca
Summary
The purpose of this study is to evaluate the effect of tozorakimab, as an add-on to SoC in patients with viral lung infection requiring supplemental oxygen, on the prevention of death or progression to IMV/ECMO.
Official title: A Phase III, Multicentre, Randomised, Double-blind, Parallel-group, Placebo-controlled Study to Evaluate the Efficacy and Safety of Tozorakimab (MEDI3506) in Patients Hospitalised for Viral Lung Infection Requiring Supplemental Oxygen
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
3527
Start Date
2022-12-13
Completion Date
2027-11-04
Last Updated
2026-10-02
Healthy Volunteers
No
Interventions
Tozorakimab
Single IV dose of tozorakimab on Day 1.
Placebo
Single IV dose of matching placebo on Day 1.
Locations (471)
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Birmingham, Alabama, United States
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Mobile, Alabama, United States
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Phoenix, Arizona, United States
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Phoenix, Arizona, United States
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Tucson, Arizona, United States
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Chula Vista, California, United States
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Fresno, California, United States
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La Mesa, California, United States
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Los Angeles, California, United States
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Newport Beach, California, United States
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Torrance, California, United States
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Colorado Springs, Colorado, United States
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Denver, Colorado, United States
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Washington D.C., District of Columbia, United States
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Bradenton, Florida, United States
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Bradenton, Florida, United States
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Gainesville, Florida, United States
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Jacksonville, Florida, United States
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Lakeland, Florida, United States
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Miami, Florida, United States
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South Pasadena, Florida, United States
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St. Petersburg, Florida, United States
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Tampa, Florida, United States
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Atlanta, Georgia, United States
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Boise, Idaho, United States
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Chicago, Illinois, United States
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Elmhurst, Illinois, United States
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Evanston, Illinois, United States
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Fort Wayne, Indiana, United States
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Iowa City, Iowa, United States
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Kansas City, Kansas, United States
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Louisville, Kentucky, United States
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Baton Rouge, Louisiana, United States
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New Orleans, Louisiana, United States
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Shreveport, Louisiana, United States
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Annapolis, Maryland, United States
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Silver Spring, Maryland, United States
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Springfield, Massachusetts, United States
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Worcester, Massachusetts, United States
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Detroit, Michigan, United States
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Detroit, Michigan, United States
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Royal Oak, Michigan, United States
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Saint Paul, Minnesota, United States
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Columbia, Missouri, United States
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Kansas City, Missouri, United States
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St Louis, Missouri, United States
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Brooklyn, New York, United States
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Buffalo, New York, United States
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New York, New York, United States
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New York, New York, United States
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Potsdam, New York, United States
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Chapel Hill, North Carolina, United States
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Durham, North Carolina, United States
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Greenville, North Carolina, United States
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Winston-Salem, North Carolina, United States
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Cleveland, Ohio, United States
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Columbus, Ohio, United States
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Toledo, Ohio, United States
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Oklahoma City, Oklahoma, United States
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Corvallis, Oregon, United States
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Portland, Oregon, United States
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Philadelphia, Pennsylvania, United States
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Pittsburgh, Pennsylvania, United States
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Providence, Rhode Island, United States
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Providence, Rhode Island, United States
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Greenville, South Carolina, United States
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Sioux Falls, South Dakota, United States
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Amarillo, Texas, United States
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Dallas, Texas, United States
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Dallas, Texas, United States
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El Paso, Texas, United States
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Houston, Texas, United States
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Houston, Texas, United States
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Salt Lake City, Utah, United States
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Salt Lake City, Utah, United States
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Charlottesville, Virginia, United States
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Green Bay, Wisconsin, United States
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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Buenos Aires, Argentina
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CABA, Argentina
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CABA, Argentina
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La Plata, Argentina
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Rosario, Argentina
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Adelaide, Australia
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Bedford Park, Australia
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New Lambton Heights, Australia
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Port Macquarie, Australia
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South Brisbane, Australia
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Kortrijk, Belgium
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Ottignies, Belgium
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Roeselare, Belgium
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Yvoir, Belgium
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Belo Horizonte, Brazil
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Campinas, Brazil
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Caxias do Sul, Brazil
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Curitiba, Brazil
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Curitiba, Brazil
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Indaiatuba, Brazil
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Jaú, Brazil
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Natal, Brazil
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Niterói, Brazil
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Passo Fundo, Brazil
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Porto Alegre, Brazil
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Porto Alegre, Brazil
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Recife, Brazil
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Ribeirão Preto, Brazil
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Rio de Janeiro, Brazil
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Salvador, Brazil
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São Caetano do Sul, Brazil
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São José do Rio Preto, Brazil
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São Paulo, Brazil
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São Paulo, Brazil
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Montana, Bulgaria
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Pernik, Bulgaria
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Pleven, Bulgaria
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Rousse, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Sofia, Bulgaria
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Varna, Bulgaria
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Calgary, Alberta, Canada
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New Westminster, British Columbia, Canada
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Winnipeg, Manitoba, Canada
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Winnipeg, Manitoba, Canada
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Winnipeg, Manitoba, Canada
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Brampton, Ontario, Canada
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Ottawa, Ontario, Canada
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Ottawa, Ontario, Canada
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Toronto, Ontario, Canada
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Lévis, Quebec, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Montreal, Quebec, Canada
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Québec, Quebec, Canada
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Saskatoon, Saskatchewan, Canada
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Anyang, China
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Beijing, China
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Beijing, China
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Beijing, China
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Beijing, China
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Changchun, China
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Changsha, China
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Changsha, China
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Chengdu, China
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Chengdu, China
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Chongqing, China
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Chongqing, China
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Fuyang, China
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Guangzhou, China
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Guangzhou, China
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Haikou, China
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Hangzhou, China
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Hangzhou, China
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Hefei, China
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Jinhua, China
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Jining, China
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Nanchang, China
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Nanjing, China
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Nantong, China
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Ningbo, China
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Qingdao, China
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Shanghai, China
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Shanghai, China
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Shanghai, China
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Shanghai, China
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Shanghai, China
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Shenzhen, China
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Tianjin, China
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Weifang, China
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Wuhan, China
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Wuhan, China
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Xinxiang, China
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Yangzhou, China
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Yantai, China
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Yinchuan, China
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Yueyang, China
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Zhengzhou, China
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Bogota DC, Colombia
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Floridablanca, Colombia
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Medellín, Colombia
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