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Efficacy of Azelastine and Mometasone Irrigation in Comparison to Nasal Sprays in Patients With Chronic Rhinitis
Sponsor: Endeavor Health
Summary
The goal of this clinical trial is to determine the best combination of drugs and drug delivery routes to treat surgically naive chronic rhinitis patients. The main question it aims to answer is: Do high volume, high pressure delivery mechanisms in nasal irrigation improve the efficacy of azelastine combined with nasal steroid mometasone as compared to the standard low pressure, low volume delivery mechanisms in nasal sprays? Subjects will complete six months of one of three medication regimens: 1. Saline irrigation followed by azelastine spray and mometasone spray 2. Mometasone saline irrigation 3. Azelastine saline irrigation combined with mometasone saline irrigation.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
81
Start Date
2022-11-23
Completion Date
2026-08
Last Updated
2023-07-28
Healthy Volunteers
Yes
Conditions
Interventions
Azelastine (137 mcg/spray) Nasal Spray and Mometasone (50 mcg/spray) Nasal Spray
Participants will follow this medication regimen for 6 months.
Mometasone Nasal Irrigation (1 mg capsule)
Participants will follow this medication regimen for 6 months.
Mometasone (1 mg) and Azelastine (1 mg) Nasal Irrigation
Participants will follow this medication regimen for 6 months.
Locations (1)
Northshore University HealthSystem
Evanston, Illinois, United States