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Hypothalamic Amenorrhea as a Fertility Status Marker for Cardiovascular Health (ARCH)
Sponsor: Mayo Clinic
Summary
Hypothalamic amenorrhea (HA) occurs during reproductive years and results in stopped menstrual cycles and infertility which can be prolonged from months to years and is characterized by varying combinations of psychosocial stress, anxiety, high levels of physical activity, and/or weight loss. Data from our group indicates that one-third of women with HA (mean age: 27 yrs) have preclinical cardiovascular disease (CVD) measured noninvasively as vascular dysfunction and vascular inflammation. This study will use HA as a marker of fertility status for cardiovascular health and perform dense-phenotyping using remote patient monitoring (FitBit) and patient reported outcomes (questionnaires) to determine which HA phenotypes are related to preclinical CVD and inflammation.
Official title: Hypothalamic Amenorrhea as a Fertility Status Marker for Cardiovascular Health
Key Details
Gender
FEMALE
Age Range
18 Years - 40 Years
Study Type
OBSERVATIONAL
Enrollment
90
Start Date
2023-01-17
Completion Date
2026-05
Last Updated
2026-04-06
Healthy Volunteers
No
Conditions
Locations (1)
Mayo Clinic Florida
Jacksonville, Florida, United States