Clinical Research Directory

Inclusion Criteria: * Written informed consent. * Presence of at least one CTO located at the proximal to midpart of left artery descending (LAD), or at proximal left circumflex (LCX), or at proximal to midpart LCX in left dominant system, or at proximal to distal right coronary artery (RCA). * LVEF \<50% (assessed within 6 weeks prior to enrolment by transthoracic echocardiography (TTE) (Simpson biplane method) or cardiac magnetic resonance imaging (cMRI). * In patients with multivessel disease (MVD) and Syntax I score ≥ 22, and all patients with type 2 diabetes and coronary 3 vessel disease, a heart team decision favouring CTO-PCI is needed. * Mandatory baseline imaging assessment (assessed within 6 weeks prior to enrolment): * TTE: Normal wall motion or hypokinesia in the CTO-territory. * In case of severe hypokinesia, akinesia or dyskinesia a viability testing with cMRI or myocardial scintigraphy (MS) indicating at least 50% of viability in the CTO territory (mandatory only in the presence of akinesia in the CTO-territory assessed by prior TTE) prior to PCI is mandatory. * Symptoms including dyspnea (according to the New York Heart Association (NYHA), classes II-III) or angina pectoris (according to Canadian Cardiovascular Society (CCS), classes II-IV). * In the absence of symptoms evidence of myocardial ischemia of at least 10% is needed being assessed by invasive or non-invasive imaging, such as stress-MRI, PET-CT-scan, myocardial scintigraphy, stress-echocardiography Exclusion Criteria: * Age \<18 and \>90 years. * Akinesia or dyskinesia assessed by TTE plus subendocardial late gadolinium enhancement of \>50% assessed by cMRI or MS in the CTO-territory or any evidence of transmural scarring of the CTO-territory (i.e. 100%). * Presence of terminal kidney disease with need for renal replacement therapy. * Severe chronic kidney disease (defined as GFR \< 25 ml/min). * Type I myocardial infarction (ST segment elevation or non-ST segment elevation myocardial infarction (STEMI or NSTEMI)) related to critical arteriosclerosis \< 30 days. * End-stage heart failure (defined by constant administration of intravenous inotropes, use of prolonged assist devices (more than 5 days), listing for high urgent cardiac transplantation). * Cardiogenic shock (\< 30 days). * Heart team decision favoring CABG surgery (in the presence of coronary multivessel disease with intermediate to high SYNTAX I score). * Grade II-III heart valve disorders requiring interventional or surgical treatment within 3 months. * Right-sided heart failure with echocardiographic evidence of severe right ventricular dysfunction. * COPD requiring long-term oxygen therapy. * Non-cardiac comorbidity with life expectancy \< 12 months.