Clinical Research Directory

Inclusion Criteria: 1. Patients with diagnosis of epithelial ovarian carcinoma, peritoneal carcinoma, or fallopian tube carcinoma within 3 lines recurrence; 2. Recurrence occurred within 6 months since platinum-based chemotherapy; 3. R0 ideal debulking in initial surgery; PET-CT indicate the recurrence lesion is almost in abdominal cavity, which is isolated and not exceed 5 sites, and the ascites is less than 500ml; 4. ECOG/WHO Performance score of 0 to 1; 5. Hematology function: Leukocyte≥ 3,5x10⁹/L, neutrophil≥ 1,5x10⁹/L, platelets ≥ 100x10⁹/L; 6. No Renal insufficiency: serum creatinine \< 1,5 time the normal limit, creatinine clearance \> 60 mL/min; 7. No hepatic failure: bilirubin ≤ 1,5 time the Normal limit; 8. Patients with good compliance; 9. Patients having read, signed and dated Informed consent before any study procedure. Exclusion Criteria: 1. Platinum-refractory/uncontrolled epithelial ovarian cancer; 2. Mucous carcinoma or low-grade serous carcinoma; 3. Suffering from other malignant tumors that have not achieved complete remission in the past 2 years; 4. Patients have received abdominal or pelvic radiotherapy; 5. General conditions cannot tolerate cytoreduction; 6. Severe hypersensitivity reactions (≥ grade 3) to paclitaxel or platinum and/or any of its excipients; 7. Unable or unwilling to sign the informed consent form; 8. Patients judged by the investigator to be unlikely to follow the research steps, restrictions and requirements.