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Study of Novel Treatment Combinations in Patients With Lung Cancer
Sponsor: Gilead Sciences
Summary
The goal of this platform clinical trial is to test how well novel treatment combinations work in participants with lung cancer. Substudy-01 will compare the different novel combinations versus standard of care in participants with metastatic (cancer that has spread) non-small-cell lung cancer (NSCLC) who have not been treated before. Substudy-02 will compare the different novel combination versus standard of care in participants with cancer that has progressed after receiving previous treatment for metastatic NSCLC. Substudy-03 will compare the different novel combinations versus standard of care in participants with resectable stage II-III NSCLC. The primary objectives of this study are: Substudy-01 and Substudy-02: To evaluate the objective response rate (ORR) assessed per Response Evaluation Criteria in Solid Tumors Version 1.1 (RECIST v1.1). Substudy-03: To evaluate the efficacy of treatment combinations based on complete pathological response (pCR) rate.
Official title: A Phase 2 Platform Study Evaluating the Safety and Efficacy of Novel Treatment Combinations in Patients With Lung Cancer (VELOCITY-Lung)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
270
Start Date
2023-03-16
Completion Date
2029-09
Last Updated
2026-03-17
Healthy Volunteers
No
Conditions
Interventions
Zimberelimab (ZIM)
Administered intravenously
Domvanalimab (DOM)
Administered intravenously
Sacituzumab govitecan-hziy (SG)
Administered intravenously
Etrumadenant (ETRUMA)
Administered orally
Carboplatin
Administered intravenously
Cisplatin
Administered intravenously
Pemetrexed
Administered intravenously
Paclitaxel
Administered intravenously
Nab-paclitaxel
Administered intravenously
Docetaxel
Administered intravenously
Nivolumab
Administered intravenously
Locations (100)
Arizona Oncology Associates,Substudy-01
Tucson, Arizona, United States
Arizona Oncology Associates,Substudy-02
Tucson, Arizona, United States
Rocky Mountain Cancer Center,Substudy-01
Denver, Colorado, United States
Rocky Mountain Cancer Center,Substudy-02
Denver, Colorado, United States
Fort Wayne Medical Oncology and Hematology, Inc.,Substudy-03
Fort Wayne, Indiana, United States
Baptist Health Lexington,Substudy-03
Lexington, Kentucky, United States
Washington University School of Medicine - Siteman Cancer Center,Substudy-01
St Louis, Missouri, United States
Washington University School of Medicine - Siteman Cancer Center,Substudy-02
St Louis, Missouri, United States
Washington University School of Medicine - Siteman Cancer Center,Substudy-03
St Louis, Missouri, United States
Washington University School of Medicine - Siteman Cancer Center
St Louis, Missouri, United States
Oncology Hematology Care Clinical Trials, LLC,Substudy-01
Cincinnati, Ohio, United States
Oncology Hematology Care Clinical Trials, LLC,Substudy-02
Cincinnati, Ohio, United States
Oncology Associates of Oregon, PC,Substudy-01
Eugene, Oregon, United States
Oncology Associates of Oregon, PC,Substudy-02
Eugene, Oregon, United States
Texas Oncology - Central South,Substudy-01
Austin, Texas, United States
Texas Oncology - Central South,Substudy-02
Austin, Texas, United States
US Oncology Investigational Products Center (IPC),Substudy-01
Fairfax, Virginia, United States
US Oncology Investigational Products Center (IPC),Substudy-02
Fairfax, Virginia, United States
Fred Hutchinson Cancer Center,Substudy-01
Seattle, Washington, United States
Fred Hutchinson Cancer Center,Substudy-02
Seattle, Washington, United States
Fundação Pio XII - Hospital de Amor,Substudy-01
Barretos, Brazil
Centro Gaúcho Integrado de Oncologia Hematologia, Ensino e Pesquisa Ltda./Hospital Mãe de Deus,Substudy-03
Porto Alegre, Brazil
Hospital Mae de Deus,Substudy-01
Porto Alegre, Brazil
Hospital Mae de Deus
Porto Alegre, Brazil
Hospital Sao Lucas da PUC Rio Grande do Sul,Substudy-01
Porto Alegre, Brazil
Hospital Sao Lucas da PUC Rio Grande do Sul,Substudy-03
Porto Alegre, Brazil
BP-A Beneficencia Portuguesa De Sao Paulo,Substudy-01
São Paulo, Brazil
Fundação Antonio Prudente - Hospital do Câncer AC Camargo,Substudy-01
São Paulo, Brazil
Fundação Antonio Prudente/A.C. Camargo Cancer Center,Substudy-03
São Paulo, Brazil
Real e Benemérita Associação Portuguesa de Beneficência/Hospital Beneficência Portuguesa de São Paulo (Hospital BP),Substudy-03
São Paulo, Brazil
Queen Mary Hospital,Substudy-01
Hong Kong, Hong Kong
Queen Mary Hospital,Substudy-02
Hong Kong, Hong Kong
Queen Elizabeth Hospital,Substudy-01
Hong Kong, Hong Kong
Queen Elizabeth Hospital,Substudy-02
Hong Kong, Hong Kong
Prince of Wales Hospital,Substudy-01
New Territories, Hong Kong
Prince of Wales Hospital,Substudy-02
New Territories, Hong Kong
Rambam Health Care Campus,Substudy-01
Haifa, Israel
Rambam Health Care Campus,Substudy-02
Haifa, Israel
Rambam Health Care Campus,Substudy-03
Haifa, Israel
Shaare Zedek Medical Center,Substudy-01
Jerusalem, Israel
Shaare Zedek Medical Center,Substudy-02
Jerusalem, Israel
Shaare Zedek Medical Center,Substudy-03
Jerusalem, Israel
Hadassah Medical Center,Substudy-01
Jerusalem, Israel
Hadassah University Medical Center,Substudy-03
Jerusalem, Israel
Rabin Medical Center,Substudy-03
Petah Tikva, Israel
Tel Aviv Sourasky Medical Center,Substudy-01
Tel Aviv, Israel
Tel Aviv Sourasky Medical Center,Substudy-02
Tel Aviv, Israel
Tel-Aviv Sourasky Medical Center,Substudy-03
Tel Aviv, Israel
Chungbuk National University Hospital,Substudy-01
Cheongju-si, South Korea
Chungbuk National University Hospital,Substudy-02
Cheongju-si, South Korea
National Cancer Center,Substudy-01
Goyang, South Korea
National Cancer Center,Substudy-02
Goyang, South Korea
National Cancer Center,Substudy-03
Goyang, South Korea
Chonnam National University Hwasun Hospital,Substudy-01
Gwangju, South Korea
Chonnam National University Hwasun Hospital,Substudy-03
Gwangju, South Korea
Seoul National University Bundang Hospital,Substudy-01
Gyeonggi-do, South Korea
Seoul National University Bundang Hospital,Substudy-03
Gyeonggi-do, South Korea
Kosin University Gospel Hospital,Substudy-01
Seogu, South Korea
Kosin University Gospel Hospital,Substudy-03
Seogu, South Korea
Severance Hospital, Yonsei University Health System,Substudy-03
Seoul, South Korea
Asan Medical Center,Substudy-02
Seoul, South Korea
Asan Medical Center,Substudy-03
Seoul, South Korea
Asan Medical Centre,Substudy-01
Seoul, South Korea
Samsung Medical Center,Substudy-01
Seoul, South Korea
Samsung Medical Center,Substudy-02
Seoul, South Korea
Samsung Medical Center,Substudy-03
Seoul, South Korea
Severance Hospital, Yonsei University Health System,Substudy-01
Seoul, South Korea
Severance Hospital, Yonsei University Health System,Substudy-02
Seoul, South Korea
Seoul National University,Substudy-01
Seoul, South Korea
Seoul National University,Substudy-02
Seoul, South Korea
Korea University Guro Hospital,Substudy-01
Seoul, South Korea
Korea University Guro Hospital,Substudy-03
Seoul, South Korea
Changhua Christian Hospital,Substudy-01
Changhua, Taiwan
Changhua Christian Hospital,Substudy-02
Changhua, Taiwan
Changhua Christian Hospital,Substudy-03
Changhua, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital,Substudy-01
Kaohsiung City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital,Substudy-02
Kaohsiung City, Taiwan
Kaohsiung Medical University Chung-Ho Memorial Hospital,Substudy-03
Kaohsiung City, Taiwan
Kaohsiung Chang Gung Memorial Hospital,Substudy-01
Kaohsiung City, Taiwan
Kaohsiung Chang Gung Memorial Hospital,Substudy-02
Kaohsiung City, Taiwan
Kaohsiung Chang Gung Memorial Hospital,Substudy-03
Kaohsiung City, Taiwan
National Taiwan University Hospital,Substudy-01
Taipei, Taiwan
National Taiwan University Hospital,Substudy-02
Taipei, Taiwan
Adana City Training and Research Hospital,Substudy-01
Adana, Turkey (Türkiye)
Memorial Ankara Hastanesi,Substudy-01
Ankara, Turkey (Türkiye)
Memorial Ankara Hospital,Substudy-03
Ankara, Turkey (Türkiye)
Medical Park Samsun,Substudy-01
Atakum, Turkey (Türkiye)
Dicle University,Substudy-01
Diyarbakır, Turkey (Türkiye)
Dicle University Medical Faculty,Substudy-03
Diyarbakır, Turkey (Türkiye)
Necmettin Erbakan University Meram Faculty of Medicine,Substudy-01
Konya, Turkey (Türkiye)
Necmettin Erbakan Universitesi,Substudy-03
Meram Konya, Turkey (Türkiye)
Gazi University Medical Faculty,Substudy-01
Yenimahalle, Turkey (Türkiye)
Gazi University Medical Faculty,Substudy-03
Yenimahalle, Turkey (Türkiye)
Birmingham Heartlands Hospital,Substudy-03
Birmingham, United Kingdom
University Hospitals Birmingham NHS Trust,Substudy-01
Birmingham, United Kingdom
University Hospitals Birmingham NHS Trust,Substudy-02
Birmingham, United Kingdom
St James University Hospital,,Substudy-01
Leeds, United Kingdom
St. Bartholomew's Hospital,Substudy-01
London, United Kingdom
St. Bartholomew's Hospital,Substudy-02
London, United Kingdom
St. Bartholomew's Hospital,Substudy-03
London, United Kingdom