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NO AD: Use of Nitric Oxide (NO) Donors for the Prevention of Autonomic Dysreflexia (AD) During Bowel Care Following SCI
Sponsor: Simon Fraser University
Summary
This project aims to evaluate the safety and efficacy of using a short-acting drug to reduce the maximal blood pressure during dangerous blood pressure spikes that happen during bowel care in individuals with spinal cord injury. the investigators will monitor the physiological effects of this drug during at-home bowel care to best understand the drug's effects in typical use.
Key Details
Gender
All
Age Range
19 Years - 80 Years
Study Type
INTERVENTIONAL
Enrollment
26
Start Date
2025-09
Completion Date
2026-02
Last Updated
2024-11-29
Healthy Volunteers
No
Interventions
Glyceryl Trinitrate Only Product in Oromucosal Dose Form
Glyceryl trinitrate will be administered via sublingual spray.
Placebo sublingual spray
A placebo sublingual spray will be administered.