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The Origin and Role of Thromboembolism in the Pathogenesis of Ischaemic Stroke
Sponsor: University of Edinburgh
Summary
Ischaemic stroke is usually due to occlusion of a cerebral artery by thrombus. However, it is often difficult to identify the source of thrombus, or to confirm thrombus as a cause of ischaemic stroke. Moreover, it is debated whether thrombosis plays any role in certain types of stroke such as lacunar stroke. In preliminary studies, the investigators have evaluated a novel clinical grade thrombus-specific radiotracer, 18F-GP1, which has a high specificity for the glycoprotein IIb/IIIa receptor on activated platelets. The investigations have demonstrated that 18F-GP1 is highly sensitive to in vivo thrombus formation and demonstrates avid binding to thrombus associated with myocardial infarction, pulmonary embolism and aortic bioprosthesis. This study will use this imaging approach to define the role and origin of thrombus in patients with ischaemic stroke, cryptogenic stroke and lacunar stroke.The investigators will also assess its added clinical value in assessing patients with ischaemic stroke.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
120
Start Date
2023-02-28
Completion Date
2026-08-01
Last Updated
2025-12-02
Healthy Volunteers
No
Conditions
Interventions
18F-GP1 PET/CT
Patient will receive 1 18F-GP1 PET/CT
Agitated Contrast Echocardiogram
Agitated saline and ultrasound contrast will be performed to assess for intracardiac shunts and left ventricular thrombus.
MRI Head
Where necessary, if the CT head is normal or the clinical diagnosis of a stroke is not definite, a research MRI head will be undertaken if this has not already been performed as part of standard care.
ECG Monitoring
All patients who do not have evidence of atrial fibrillation or atrial flutter on their 12-lead ECG will undergo an ECG Holter monitor for up to 7 days. This will be part of their standard care. If this has not been arranged by the usual care team this will be performed as a research procedure.
Locations (1)
Clinical Research Facility
Edinburgh, United Kingdom