Clinical Research Directory

Inclusion Criteria: * 40 years of age, male and female * Left ventricular ejection fraction (LVEF) ≥ 50% * Symptoms and signs of heart failure * N-terminal pro-B-type natriuretic peptide (NT-proBNP) ≥300 pg/ml at baseline (patients in atrial fibrillation at baseline NT-proBNP ≥ 600 pg/ml), left atrial volume index (LAVI) \>34 mL/m2 or a left ventricular mass index (LVMI) =115 g/m2 for males and =95 g/m2 for females * body mass index (BMI) \> 30kg/m2 or diabetes mellitus Exclusion Criteria: * Hypertrophic cardiomyopathy, constrictive pericarditis, or cardiac amyloidosis * Acute decompensation of HF in the last 1 month * Valvular heart disease * Prior history of LVEF below 50% * Acute myocardial infarction in the last 3 months, cardiac surgery or cerebrovascular accident within the recent 6 months * Any active or chronic inflammatory diseases or infections * Patients with indication for colchicine therapy or history of colchicine intolerance * Severe hepatic (alanine aminotransferase N3 upper limit of normal or renal dysfunction (estimated glomerular filtration rate \<45 mL/min per 1.73m2) * Severe nervous system diseases * History of any malignancy or suffering from cancer * Lack of informed consent