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Dupilumab Step-down Strategy to Maintain Remission in Adult and Adolescents Patients With Atopic Dermatitis
Sponsor: Nantes University Hospital
Summary
The goal of this clinical trial is to compare a step-down strategy of spacing dupilumab injections with a standard maintenance treatment in adolescents and adults with controlled Atopic dermatitis (AD) for at least six months. The impact of dosage reduction strategies will be assessed with an innovative primary endpoint: the area under the curve of the weekly ADCT assessment.
Official title: Dupilumab Step-down Strategy to Maintain Remission in Adult and Adolescents Patients With Atopic Dermatitis: a Non-inferiority Randomized Trial
Key Details
Gender
All
Age Range
12 Years - Any
Study Type
INTERVENTIONAL
Enrollment
256
Start Date
2023-03-08
Completion Date
2026-09-08
Last Updated
2025-09-11
Healthy Volunteers
No
Conditions
Interventions
Dupilumab step-down
step down dupilumab injections
Locations (32)
Amiens University hospital
Amiens, France
CHU d'Angers
Angers, France
Hôpital Victor Dupouy
Argenteuil, France
CHU de Besançon
Besançon, France
CHU de Bordeaux Adulte
Bordeaux, France
CHRU de Brest
Brest, France
CHU de Clermont Ferrand
Clermont-Ferrand, France
CHU de Dijon
Dijon, France
CHU de Grenoble
Grenoble, France
CHD Vendée
La Roche-sur-Yon, France
GH La Rochelle - Ré-Aunis
La Rochelle, France
CH de Le Mans
Le Mans, France
CHRU de Lille
Lille, France
Groupement des Hôpitaux de l'institut Catholique de Lille
Lille, France
Hospices Civils de Lyon
Lyon, France
Hôpital de la Timone
Marseille, France
CHU de Montpellier
Montpellier, France
CHU de Nantes
Nantes, France
CH de Niort
Niort, France
Hôpital Cochin
Paris, France
Hôpital Necker-Enfants malades
Paris, France
Hôpital Saint Louis
Paris, France
Hôpital Tenon
Paris, France
CHU de Poitiers
Poitiers, France
CHU de Reims
Reims, France
CHU de Rennes
Rennes, France
CHU de Rouen
Rouen, France
CH de Saint Nazaire
Saint-Nazaire, France
HIA Sainte Anne
Toulon, France
CHU de Toulouse - Hôpital Larrey
Toulouse, France
CHRU de Tours
Tours, France
CHU de La Réunion
Saint-Pierre, La Réunion, Reunion