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ZYNRELEF for Pain Management in Total Knee Arthroplasty
Sponsor: Baptist Health South Florida
Summary
The goal of this randomized controlled trial is to compare opioid medication consumption after surgery for patients who have a total knee replacement. The main questions it aims to answer are: * How well does the study drug control pain in the days after surgery? * Does the study drug reduce the amount of opioid analgesic consumed after surgery? Participants in the study group will undergo a total knee replacement as planned with their surgeon. In addition, be given the study drug, Zynrelef (combination of bupivacaine and meloxicam). Researchers will compare the above to a control group who will have a total knee replace only according to usual standards to see if there are any differences in the amount of a type of pain medication (opioid analgesic) consumed in the days following surgery.
Official title: A Randomized Controlled Trial of ZYNRELEF Versus Standard of Care for Pain Management Following Unilateral Total Knee Arthroplasty
Key Details
Gender
All
Age Range
35 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
242
Start Date
2023-03-09
Completion Date
2027-12
Last Updated
2025-04-18
Healthy Volunteers
No
Conditions
Interventions
Bupivacaine-Meloxicam 400 Mg-12 Mg/14 mL Injectable Solution, Extended Release
Instillation of the drug into the knee joint capsule and surrounding tissues after placing the knee prosthesis and before close of the surgical wound
Locations (1)
Doctors Hospital
Miami, Florida, United States