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MAnagement of Systolic Blood Pressure During Thrombectomy by Endovascular Route for Acute Ischaemic STROKE
Sponsor: Auckland City Hospital
Summary
Stroke is the third most common cause of death in New Zealand and is one of the leading causes of long-term disability at all ages. A life-saving clot retrieval procedure can save lives and prevent disability of patients with ischaemic stroke who get to hospital in time. In New Zealand, 90% of clot retrieval procedures are performed under general anaesthesia. Many anaesthetic drugs can affect blood pressure (BP) and blood flow within the brain. Increasing BP during the procedure could provide additional benefits in this devastating disease. A large trial is needed to investigate BP management during clot retrieval.
Official title: MAnagement of Systolic Blood Pressure During Thrombectomy by Endovascular Route for Acute Ischaemic STROKE: the MASTERSTROKE Trial
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
550
Start Date
2019-11-28
Completion Date
2026-02-28
Last Updated
2026-01-05
Healthy Volunteers
No
Conditions
Interventions
Blood pressure management of Systolic Blood Pressure to maintain target range +/- 10 mmHg
Techniques used to target SBP will not be controlled for and will be at the discretion of the procedural anaesthetist to manage blood pressure, this can include vasopressors, intravenous fluids, titration of anaesthetic maintenance drugs and use of other vasoactive drugs.
Locations (6)
Royal North Shore Hospital
Sydney, New South Wales, Australia
Gold Coast University Hospital
Southport, Queensland, Australia
Metro South Hospital and Health Service via the Princess Alexandra Hospital
Woolloongabba, Queensland, Australia
Auckland City Hopsital
Auckland, Auckland, New Zealand
Christchurch Hospital
Christchurch, Canterbury, New Zealand
Wellington Regional Hospital
Newton, Wellington Region, New Zealand