Clinical Research Directory
Browse clinical research sites, groups, and studies.
A Research Study to See How Semaglutide Helps People With Excess Weight, Lose Weight (STEP UP)
Sponsor: Novo Nordisk A/S
Summary
This study will look at how much weight participants will lose from the start to the end of the study. The weight loss in participants taking the investigational high dose of semaglutide will be compared to the weight loss in people taking "dummy" medicine and a lower dose of semaglutide. In addition to taking the medicine, participants will have talks with study staff about healthy food choices and how to be more physically active. Participants will either get semaglutide or "dummy" medicine. Which treatment participants get is decided by chance. Participants are more likely (4 out of 5) to get semaglutide than the "dummy" medicine. The study medicine will be injected briefly, under skin, with a thin needle, typically in the stomach, thighs, or upper arms. In the first part of the study, participants will get one injection once a week until they reach the planned dose. The second part of the study, which might last a couple of months, is a transition period, where participant will get three injections, taken right after each other, once a week. The duration of the study intervention (trial product and lifestyle intervention) will be 72 weeks followed by a 9-week follow-up period without study interventions.
Official title: Effect and Safety of Semaglutide 7.2 mg Once-weekly in Participants With Obesity
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
1407
Start Date
2023-01-04
Completion Date
2024-11-26
Last Updated
2026-04-23
Healthy Volunteers
No
Conditions
Interventions
Semaglutide
Participants will receive once-weekly s.c. injections of semaglutide in escalating doses (0.25 mg, 0.5 mg, 1.0 mg, 1.7 mg, 2.4 mg and 7.2 mg) every fourth week. Treatment was continued on the maintenance dose of 7.2 mg once-weekly for an additional 52 weeks. Injections may be administered in the thigh, abdomen, or upper arm, at any time of day irrespective of meals.
Semaglutide
Participants will receive once-weekly s.c. injections of semaglutide in escalating doses (0.25 mg, 0.5 mg, 1.0 mg, 1.7 mg, and 2.4 mg) every fourth week. Treatment was continued on the maintenance dose of 2.4 mg once-weekly for an additional 52 weeks. Injections may be administered in the thigh, abdomen, or upper arm, at any time of day irrespective of meals.
Placebo
Participants will receive once-weekly s.c. injection of placebo matched to semaglutide for 72 weeks. Injections may be administered in the thigh, abdomen, or upper arm, at any time of day irrespective of meals.
Locations (107)
Univ of Alabama Birmingham
Birmingham, Alabama, United States
Chambliss Clinical Trials, LLC
Montgomery, Alabama, United States
Healthscan Clinical Trials,LLC.
Montgomery, Alabama, United States
Diablo Clinical Research, Inc.
Walnut Creek, California, United States
Jacksonville Ctr For Clin Res
Jacksonville, Florida, United States
Florida Inst For Clin Res LLC
Orlando, Florida, United States
Florida Institute For Clinical Research LLC
Orlando, Florida, United States
East West Med Res Inst
Honolulu, Hawaii, United States
Midwest Inst For Clin Res
Indianapolis, Indiana, United States
AMC Community Endocrinology
Albany, New York, United States
University of North Carolina
Chapel Hill, North Carolina, United States
PharmQuest Life Sciences LLC
Greensboro, North Carolina, United States
Medical University Of South Carolina
Charleston, South Carolina, United States
Amarillo Med Spec LLP
Amarillo, Texas, United States
Elligo Clin Res Centre
Austin, Texas, United States
Velocity Clin Res, Dallas
Dallas, Texas, United States
UT Southwestern Medical Center-CRU
Dallas, Texas, United States
DCOL Ctr for Clin Res
Longview, Texas, United States
Sugar Lakes Family Practice PA
Sugar Land, Texas, United States
National Clin Res Inc.
Richmond, Virginia, United States
Selma Medical Associates
Winchester, Virginia, United States
Medical centre Zdrave 1 OOD
Kozloduy, Bulgaria
Medical center Hippocrates Lukovit EOOD
Lukovit, Bulgaria
IPMC - Dr. Elizabeta Dimitrova
Petrich, Bulgaria
Medical center Smolyan clinical research OOD
Smolyan, Bulgaria
DCC Ascendent OOD
Sofia, Bulgaria
SGHAT Dr. Shterev EOOD
Sofia, Bulgaria
Acibadem City Clinic UMHAT Tokuda EAD, Endocrinology
Sofia, Bulgaria
Medical Centre Medical Arts Medico-dental centre
Sofia, Bulgaria
Medical Center Medical Plus EOOD
Varna, Bulgaria
AIPSMC Dr. Evelina Zlatanova EOOD
Varna, Bulgaria
Ocean West Research Clinic
Surrey, British Columbia, Canada
Nova Scotia Health Authority
Halifax, Nova Scotia, Canada
Nova Scotia Hlth Halifax
Halifax, Nova Scotia, Canada
Premier Clinical Trial Research Network (PCTRN)
Hamilton, Ontario, Canada
Wharton Med Clin Trials
Hamilton, Ontario, Canada
Wharton Medical Clinic Clinical Trials (Hamilton)
Hamilton, Ontario, Canada
Hamilton Med Res Group
Hamilton, Ontario, Canada
Milestone Research
London, Ontario, Canada
Ordinace praktického lékaře
Benátky Na Jizerou, Czechia
Edumed Broumov
Broumov, Czechia
Fakultní nemocnice Královské Vinohrady_Praha 10
Prague, Czechia
Endocare
Prague, Czechia
Institut klinické a experimentalni mediciny
Prague, Czechia
Poliklinika Michnova - Obezitologie
Prague, Czechia
Fledip s.r.o.
Prague, Czechia
Medizinisches Versorgungszentrum Am Bahnhof Spandau GbR
Berlin, Germany
Zentrum fuer klinische Studien Suedbrandenburg GmbH
Elsterwerda, Germany
InnoDiab Forschung GmbH
Essen, Germany
Praxis Dr. med. M. Esser
Essen, Germany
Zentrum für klinische Forschung, Dr. med. Lüdemann
Falkensee, Germany
MedicalCenter am Clemenshospital - Schwerpunktpraxis für Diabetologie und Ernährungsmedizin
Münster, Germany
RED-Institut für medizinische Forschung und Fortbildung GmbH
Oldenburg in Holstein, Germany
Praxis Dr. med. Wenzl-Bauer
Rehlingen-Siersburg, Germany
Zentrum für klinische Studien Allgäu Oberschwaben
Wangen, Germany
Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann
Witten, Germany
University Hospital of Athens ATTIKON
Athens, Attica, Greece
Gen Hospital of Athens Laiko,1st Dpt. of Propaedeutic Inter
Athens, Greece
Iatriko Athinon (Athens Medical Canter)
Athens, Greece
Iatriko Athinon 'Palaiou Falirou'
Athens, Greece
General Hospital of Lamia
Lamia, Greece
General Hospital of Thessaloniki 'G. Gennimatas
Thessaloniki, Greece
AHEPA General University Hospital
Thessaloniki, Greece
"Ippokrateio" G.H. of Thessaloniki
Thessaloniki, Greece
"Thermi" Private Hosital
Thessaloniki, Greece
Lausmed Kft.
Baja, Bács-Kiskun county, Hungary
Belinus Bt.
Debrecen, Hajdú-Bihar, Hungary
Borbánya Praxis E.Ü. Kft.
Nyíregyháza, Szabolcs-Szatmar Varmegye, Hungary
ClinDiab Egészségügyi Szolgáltató és Kereskedelmi Kft.
Budapest, Hungary
Bajcsy-Zsilinszky Kórház
Budapest, Hungary
MED-TIMA Kft.
Budapest, Hungary
Fejér Megyei Szent György Oktatókórház
Székesfehérvár, Hungary
Falck Norge AS
Hamar, Norway
Oslo universitetssykehus HF Aker
Oslo, Norway
Sykehuset i Vestfold HF, Tønsberg
Tønsberg, Norway
Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET
Krakow, Lesser Poland Voivodeship, Poland
NZOZ Przychodnia Specjalistyczna Medica
Lublin, Lubelski, Poland
NZOZ "CenterMed Lublin" Sp. z o.o.
Lublin, Lublin Voivodeship, Poland
Kresmed Sp. z o. o.
Bialystok, Podlaskie Voivodeship, Poland
Centrum Medyczne Pratia Gdynia
Gdynia, Pomeranian Voivodeship, Poland
Uniwersyteckie Centrum Kliniczne SUM w Katowicach
Katowice, Poland
NBR Polska Tomasz Klodawski
Warsaw, Poland
PANSTWOWY INSTYTUT MEDYCZNY MSWiA
Warsaw, Poland
ULS De Matosinhos E.P.E.- Hospital Pedro Hispano
Senhora Da Hora, Matosinhos, Matosinhos, Portugal
APDP - Associação Protectora dos Diabéticos de Portugal
Lisbon, Portugal
Unidade Local De Saúde De Lisboa Ocidental E.P.E. - Hospital Egas Moniz
Lisbon, Portugal
Hospital da Luz Lisboa, S.A.
Lisbon, Portugal
ULS De São João, E.P.E. - Hospital de São João
Porto, Portugal
Hospital da Luz Arrabida, S.A.
Vila Nova de Gaia, Portugal
MUDr. Dagmar Prokesova, Endokrinologicka ambulancia
Bratislava, Slovakia
MEDIMAD, s.r.o., Endokrinologicka ambulancia
Bratislava, Slovakia
IN-DIA s.r.o.
Lučenec, Slovakia
SIN AZUCAR s.r.o.
Malacky, Slovakia
MED-CENTRUM, s.r.o.
Martin, Slovakia
SVAJDLEROVA, s.r.o.
Prešov, Slovakia
MEDIVASA, s.r.o., Angiologicka ambulancia
Žilina, Slovakia
Dom srdca, s.r.o.
Žilina, Slovakia
Phoenix Pharma
Port Elizabeth, Eastern Cape, South Africa
Medi-Clinic Bloemfontein
Bloemfontein, Free State, South Africa
Soweto Clinical Trial Centre
Johannesburg, Gauteng, South Africa