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RECRUITING
NCT05646732
NA

Targeting the Default Mode Network: A TMS-fMRI Study

Sponsor: Allyson Rosen

View on ClinicalTrials.gov

Summary

In post-traumatic stress disorder (PTSD), intrusive, traumatic, autobiographical memories lead to anxiety symptoms. Recent work suggests a new repetitive pulse transcranial magnetic stimulation (rTMS) brain target that might bring relief. Since this proposed target is not well understood, the goal of the study is to use functional magnetic resonance imaging (fMRI) to identify the brain regions and networks that change with rTMS stimulation at this target area in PTSD patients. Ultimately, this would lead to a personalized approach to rTMS treatment of PTSD based on brain imaging that can be used in a future clinical trial. Participants will be asked to complete psychological testing and questionnaires as well as an initial MRI and two separate TMS-fMRI sessions. Total participation time across all visits is estimated to be five to six hours. Research participation will take place at VA Palo Alto as well as at Stanford University.

Key Details

Gender

All

Age Range

18 Years - 55 Years

Study Type

INTERVENTIONAL

Enrollment

30

Start Date

2023-08-02

Completion Date

2025-01-31

Last Updated

2024-04-03

Healthy Volunteers

No

Interventions

DEVICE

TMS-fMRI

Participants will undergo simultaneous TMS and fMRI

Locations (1)

VA Palo Alto

Palo Alto, California, United States