Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
RECRUITING
NCT05655195
NA

Chronic Treatment of Alzheimer's Disease by Gamma Light and Sound Therapy

Sponsor: Massachusetts Institute of Technology

View on ClinicalTrials.gov

Summary

Alzheimer's disease (AD) is characterized by significant memory loss, toxic protein deposits amyloid and tau) in the brain, and changes in the gamma frequency band on EEG. The investigator's lab found that boosting gamma waves in AD mouse models using light and sound stimulation at 40Hz not only reduced amyloid and tau in the brain, but also improved memory. The investigators developed a light and sound device for humans that stimulates the brain at 40Hz that can be used safely at home. For the present study, 60 participants with mild Alzheimer's disease will be enrolled and will use this light and sound device at-home daily for 6-months. Investigators will measure changes in brain waves with EEG, blood biomarkers, the microbiome via fecal samples, functional and structural MRI scans, memory and cognitive testing, and questionnaires at 3 in-person visits throughout the study. After the 6-month time point, participants will have the option of continuing in the study for at least one year and completing yearly study visits. This study will provide critical insight into extended therapy involving non-invasive 40Hz sensory stimulation as a possible therapeutic strategy for mild to moderate Alzheimer's disease.

Official title: Chronic Treatment of Alzheimer's Disease With Gamma Frequency Stimulation

Key Details

Gender

All

Age Range

65 Years - 100 Years

Study Type

INTERVENTIONAL

Enrollment

60

Start Date

2022-12-14

Completion Date

2026-09-01

Last Updated

2026-03-30

Healthy Volunteers

Yes

Interventions

DEVICE

GENUS device (Active Settings)

Participants in the active, experimental group will use the GENUS devices configured to active (40Hz) setting for 60 minutes daily for 6 months.

DEVICE

GENUS device (sham settings)

Participants in the control group will use the GENUS devices configured to the sham settings for 60 minutes daily for 6 months.

Locations (1)

Massachusetts Institute of Technology

Cambridge, Massachusetts, United States