Clinical Research Directory
Browse clinical research sites, groups, and studies.
Utility of CYP2D6 Genotyping to Improve the Efficacy and Safety of Tramadol
Sponsor: Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Summary
Randomized clinical trial to evaluate the utility of CYP2D6 genotyping to improve the efficacy and safety of tramadol in the treatment of acute postoperative pain. Phase IV and low-intervention trial To evaluate if the implementation of pharmacogenetics in clinical practice can help to improve the treatment of acute pain, increasing efficacy and reducing adverse reactions. The main evaluation variable: This is a simple study, which does not differ from standard clinical practice and therefore we do not expect early ending of the study.
Official title: Randomized Clinical Trial to Evaluate the Utility of CYP2D6 Genotyping to Improve the Efficacy and Safety of Tramadol in the Treatment of Acute Postoperative Pain.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
300
Start Date
2022-10-05
Completion Date
2026-08-31
Last Updated
2026-08-19
Healthy Volunteers
Yes
Interventions
The patients in experimental group will be genotyped before surgery and treatment will be prescribed according to the CYP2D6 phenotype
Treatment will be prescribed according to the CYP2D6 phenotype. Normal Metabolizers (NM): Tramadol 100 mg every 8 hour; Ultrarapid Metabolizers (UM): Tramadol 50 mg every 8 hours Intermediate and poor metabolizers (IM/PM): dexketoprofen 25 mg every 8 hours
Locations (8)
Hospital Universitario Puerta de Hierro
Majadahonda, Madrid, Spain
Hospital Universitario San Juan de Alicante
Alicante, Spain
Hospital General Universitario de Burgos y Clínica Colina
Burgos, Spain
Fundación para la Investigación Biomédica Hospital La Princesa
Madrid, Spain
Hospital Univesitario Ramón y Cajal
Madrid, Spain
Hospital Universitario Clínico San Carlos
Madrid, Spain
Hostpital Universitario Fundación Jiménez Díaz
Madrid, Spain
Hospital Universitaro La Paz
Madrid, Spain