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Nasal Outcomes Using Saline Irrigations After Endonasal Pituitary Surgery
Sponsor: Lori Wood
Summary
This is a prospective, single-blinded, multicenter study evaluating the benefit of sinonasal irrigations following endoscopic pituitary surgery. The goal of this study is to create practice changing guidelines with objective data highlighting the importance of irrigations on postoperative outcomes for pituitary surgery.
Official title: Nasal Outcomes Using Saline Irrigations After Endonasal Pituitary Surgery - The NOSE Trial
Key Details
Gender
All
Age Range
19 Years - 85 Years
Study Type
INTERVENTIONAL
Enrollment
140
Start Date
2020-12-18
Completion Date
2029-12-31
Last Updated
2024-04-19
Healthy Volunteers
No
Conditions
Interventions
Nasal saline irrigation
The following nasal care recommendations have been approved by the study protocol committee for patients randomized to the treatment arm with saline irrigations: * Postoperative days 1 through 3: patients will administer saline spray (e.g., Ocean nasal spray) to both nostrils four times daily. * Postoperative day 3 to week 12: patients will begin twice daily sinus irrigation rinse (e.g., NeilMed Sinus Rinse). They will perform 240 mL sinus rinses BID. After day 30, patients will perform sinus irrigation as needed. If a patient is unable to tolerate nasal rinses, saline spray can be used as an alternative.
Locations (2)
Barrow Neurological Institute at St. Joseph's Hospital and Medical Center
Phoenix, Arizona, United States
Cleveland Clinic
Cleveland, Ohio, United States