Clinical Research Directory

Inclusion Criteria: * Informed Consent as documented by signature (Appendix Informed Consent Form) * Age older than 16 years old, * Symptomatic knee osteoarthritis confirmed by magnetic resonance imaging (MRI) * Absence of free or displaced meniscal or cartilage fragments on the MRI of the affected knee * Failure of first-line conservative management in the last 3 months including medical or infiltrative treatment, orthotics use, active rehabilitation plan, adaptation of sports and work habits. Exclusion Criteria: * Patient is familiar with the lipoaspiration process * Significant disease of the contralateral member with a function evaluated with SANE score below 80% * Microcristalline disease (i.e. gout, pseudogout), * Active inflammatory rheumatic disorders, * Need of regular anti-inflammatory treatment (either NSAIDs or corticosteroids), * Allergy to local anesthetics or epinephrin * Bleeding disorders or current anticoagulation therapy * Patients with decompensated renal failure, hepatic dysfunction, or severe pulmonary or cardiovascular disease, * Patients with an immunocompromised status * Women who are pregnant or intend to become pregnant during the study * Inability to follow the procedures of the study, e.g., due to language problems, psychological disorders, dementia, etc. of the participant, * Known or suspected non-compliance, drug, or alcohol abuse * Previous enrollment into the current study, * Participation in another study with investigational drug or procedure within the 30 days preceding and during the present study * Enrollment of the investigator, his/her family members, employees, and other dependent persons If a bilateral disease is present and both sides require either the experimental or the control intervention, only the most symptomatic side will be studied.