Clinical Research Directory
Browse clinical research sites, groups, and studies.
Neurobiological Markers of Treatment Response for Anxiety and OCD
Sponsor: Haukeland University Hospital
Summary
Obsessive-compulsive disorder (OCD) and anxiety disorders are common and debilitating conditions which are often chronic when treatment is not provided. International guidelines recommend cognitive behavioral therapy (CBT) as the first-line treatment, and research has shown that CBT can be delivered over a concentrated period of time. The Bergen 4-Day Treatment (B4DT) is an exposure-based treatment which is delivered over four consecutive days. B4DT has been shown to induce rapid and long-lasting remission in around 70% of patients. This provides a platform for studying psychological and neurobiological changes associated with treatment response and non-response. The present study will investigate longitudinal changes in psychological measures and DNA methylation in patients who receive the B4DT, as well as a subset will also undergo multimodal brain imaging.
Key Details
Gender
All
Age Range
16 Years - Any
Study Type
OBSERVATIONAL
Enrollment
500
Start Date
2018-03-23
Completion Date
2027-12-11
Last Updated
2022-12-23
Healthy Volunteers
Yes
Interventions
Bergen 4-Day Treatment (B4DT)
A concentrated and exposure-based psychological treatment over four consecutive days
Locations (1)
Bergen Center for Brain Plasticity
Bergen, Vestland, Norway