Clinical Research Directory

Inclusion Criteria: * Patient aged 18 years or older; * Wearing a permanent prosthesis for more than 6 months; - Consultant in the ophthalmology department; * Modified OSDI score ≥ 20 points out of 40 ; * Affiliated with a health insurance scheme, * For women of childbearing age: effective contraception (effective contraception includes oral contraception, intrauterine devices and other forms of contraception with a failure rate \<1%, for the duration of the study and up to 1 week after the last dose administered) * Have given free, informed and written consent. Exclusion Criteria: * Treatment with eye drop(s) (other than artificial tears or antiseptic) \< 1 month; * Concomitant treatment with CYP3A inhibitors including cobicistat containing drugs, * Known contraindications to study treatments * Dermal fat grafting or complicated cavity; * Gougerot-Sjögren syndrome; * Allergic conjunctivitis; * Damaged prosthesis; * Impossibility of carrying out the various tests required by the protocol for whatever reason (comprehension problems, motor disability); * Pregnant or breastfeeding woman; * Person already included in a RIPH1 research protocol with topical treatment of the cavity or systemic anti-inflammatory treatment and/or who could lead to a bias in the present study * Person under legal protection (safeguard of justice, curatorship, guardianship) or person deprived of liberty.