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ACTIVE NOT RECRUITING

NCT05669755

PHASE3

REDEFINE 3: A Research Study to See the Effects of CagriSema in People Living With Diseases in the Heart and Blood Vessels

Sponsor: Novo Nordisk A/S

View on ClinicalTrials.gov

Summary

This study will look at the effects of CagriSema on cardiovascular events (for example heart attack and stroke) in people living with cardiovascular disease. Participants will either get CagriSema or a dummy medicine (also called "placebo") which has no effect on the body. Which treatment participants will get will be decided by chance. Participant's chance of getting CagriSema or placebo is the same. Participants will inject the study medicine once a week. The study medicine will be injected briefly with a thin needle, typically in the stomach, thighs or upper arms. The study will last for up to 4.5 years.

Official title: The Cardiovascular Safety and Efficacy of Cagrilintide 2.4 mg s.c. in Combination With Semaglutide 2.4 mg s.c. (CagriSema 2.4 mg/2.4 mg s.c.) Once-weekly in Participants With Established Cardiovascular Disease

Key Details

Gender

All

Age Range

55 Years - Any

Study Type

INTERVENTIONAL

Enrollment

7101

Start Date

2023-03-01

Completion Date

2027-10-13

Last Updated

2026-03-12

Healthy Volunteers

Conditions

Cardiovascular Disease

Interventions

DRUG

Cagrilintide

Participants will receive cagrilintide s.c. once-weekly after a dose escalation period of 16 weeks for 219 weeks.

DRUG

Semaglutide

Participants will receive semaglutide s.c. once-weekly after a dose escalation period of 16 weeks for 219 weeks.

DRUG

Placebo

Participants will receive placebo matched to cagrilintide and placebo matched to semaglutide subcutaneously.

Inclusion Criteria: * Male or female * Age above or equal to 55 years at the time of signing informed consent * Body mass index (BMI) greater than or equal to (\>=) 25.0 kilograms per meter square (kg/m\^2) * Established CVD as evidenced by at least one of the following: 1. Prior myocardial infarction 2. Prior stroke (ischemic or haemorrhagic stroke) 3. Symptomatic peripheral arterial disease (PAD) defined as at least one of the following: 1. Intermittent claudication with an ankle-brachial index (ABI) less than (\<) 0.85 at rest 2. Intermittent claudication with a \>= 50% stenosis in a lower extremity peripheral artery documented by X-ray angiography, magnetic resonance (MR) angiography, computed tomography (CT) angiography or Doppler ultrasound 3. Prior revascularization procedure of a lower extremity peripheral artery 4. Lower extremity amputation at or above ankle due to atherosclerotic disease (excluding e.g., trauma or osteomyelitis) For participants with T2D at screening the following inclusion criteria also apply: * Diagnosed with type 2 diabetes mellitus (T2D) \>= 180 days before screening * HbA1c 6.5%-10% (47-86 millimoles per mole \[mmol/mol\]) (both inclusive), as measured by central laboratory at screening * Treatment with either: 1. Lifestyle intervention alone 2. 1-3 marketed oral antidiabetic drugs (OADs) (metformin, α-glucosidase inhibitors (AGI), glinides, sodium-glucose co-transporter 2 inhibitor (SGLT2i), dipeptidyl peptidase 4 (DPP4)-inhibitors, thiazolidinediones, or sulphonylureas (SU) as a single agent or in combination) according to local label 3. Basal insulin alone or in combination with up to two marketed OADs, all according to local label Exclusion Criteria: * Myocardial infarction, stroke, hospitalization for unstable angina pectoris or transient ischaemic attack within 60 days before screening * Planned coronary, carotid or peripheral artery revascularisation known on the day of screening * Heart failure classified as being in New York Heart Association (NYHA) Class IV at screening * Treatment with any glucagon-like peptide-1 (GLP-1) receptor agonist (RA) or a medication with GLP-1 activity within 90 days before screening * End stage renal disease defined as estimated glomerular filtration rate (eGFR) \< 15 millileters per minutes per 1.73\^2 (mL/min/1.73 m\^2), as measured by the central laboratory at screening * Chronic or intermittent haemodialysis or peritoneal dialysis

Locations (628)

Univ of Alabama Birmingham

Birmingham, Alabama, United States

Chambliss Clinical Trials LLC

Montgomery, Alabama, United States

Honor Health

Scottsdale, Arizona, United States

National Heart Institute Cal

Beverly Hills, California, United States

Valley Clinical Trials

Covina, California, United States

Scripps Wht Diab Inst La Jolla

La Jolla, California, United States

First Valley Medical Group

Lancaster, California, United States

Clinical Trials Research_Sacramento

Lincoln, California, United States

Torrance Clin Res Inst, Inc.

Lomita, California, United States

Pacific Clinical Studies

Los Alamitos, California, United States

Monterey Endocrine & Diabetes Institute, Inc

Monterey, California, United States

Valley Clinical Trials, Inc.

Northridge, California, United States

Desert Oasis Hlthcr Med Group

Palm Springs, California, United States

Western University of Health Sciences

Pomona, California, United States

Linda Vista Health Care Ctr

San Diego, California, United States

N America Res Inst - San Dimas

San Dimas, California, United States

Encompass Clinical Research_Spring Valley

Spring Valley, California, United States

Lundquist Inst.-Biom Inno-UCLA

Torrance, California, United States

Bridgeport Hospital

Bridgeport, Connecticut, United States

Innovative Research of W FL

Clearwater, Florida, United States

Florida Premier Cardiology

Delray Beach, Florida, United States

Fleming Island Center for Clinical Research

Fleming Island, Florida, United States

Life Spring Research Foundation LLC

Miami, Florida, United States

Clinical Trial Services Corp

Miami, Florida, United States

Oceane 7 Medical & Research Center, Inc.

Miami, Florida, United States

Reyes Clinical Research, Inc

Miami, Florida, United States

San Marcus Res Clin Miami Lakes

Miami Lakes, Florida, United States

Floridian Clinical Research, LLC

Miami Lakes, Florida, United States

Adult Medicine of Lake County, Inc.

Mt. Dora, Florida, United States

Suncoast Clinical Research, Inc.

New Port Richey, Florida, United States

Hanson Clinical Research Center

Port Charlotte, Florida, United States

Northeast Research Institute

Saint Augustine, Florida, United States

Cardio Partners Clin Res Inst

Wellington, Florida, United States

Endo Res Solutions Inc

Roswell, Georgia, United States

Atlanta Heart Specialists, LLC

Tucker, Georgia, United States

Rocky Mountain Diab&Osteo Ctr

Idaho Falls, Idaho, United States

Northwest Heart Clinical Research, LLC

Arlington Heights, Illinois, United States

Macoupin Research Group

Gillespie, Illinois, United States

Clinical Invest Special_Gurnee

Gurnee, Illinois, United States

Endeavor Health

Skokie, Illinois, United States

American Hlth Ntwk of IN LLC

Franklin, Indiana, United States

West Broadway Clinic

Council Bluffs, Iowa, United States

Iowa Diab & Endo Res Center

West Des Moines, Iowa, United States

Midwest Heart & Vasc Spec

Overland Park, Kansas, United States

The Research Group of Lexington LLC

Lexington, Kentucky, United States

L-MARC Research Center

Louisville, Kentucky, United States

Louisiana Heart Center

Covington, Louisiana, United States

Louisiana Heart Center

Hammond, Louisiana, United States

Tulane University Health Sciences Center

New Orleans, Louisiana, United States

Clinical Trials Of America

West Monroe, Louisiana, United States

Ascension Saint Agnes Heart Ca

Baltimore, Maryland, United States

Elite Research Center

Flint, Michigan, United States

Arcturus HC PLC Troy Med Res

Troy, Michigan, United States

NDORI

Diamondhead, Mississippi, United States

StudyMetrix Research LLC

City of Saint Peters, Missouri, United States

Clinical Research Consultants, LLC

Kansas City, Missouri, United States

Clinvest Research

Springfield, Missouri, United States

Amicis Centers of Clinical Research

St Louis, Missouri, United States

St Louis Heart & Vascular, P.C.

St Louis, Missouri, United States

VA Neb West Iowa Hlth System

Omaha, Nebraska, United States

Methodist Physicians Clin

Omaha, Nebraska, United States

Univ of NE Med Center_Omaha

Omaha, Nebraska, United States

Southern New Hampshire Diabetes and Endocrinology

Nashua, New Hampshire, United States

Renal Medicine Associates

Albuquerque, New Mexico, United States

Albany Medical College

Albany, New York, United States

Mid Hudson Med Res-New Windsor

New Windsor, New York, United States

IMA Clinical Research- NY

New York, New York, United States

Saratoga Clinical Research

Saratoga Springs, New York, United States

Prime Global Research Inc.

The Bronx, New York, United States

Southgate Medical Group, LLP

West Seneca, New York, United States

Great Lakes Medical Research

Westfield, New York, United States

UNC- Chapel Hill

Chapel Hill, North Carolina, United States

Duke University

Durham, North Carolina, United States

Carteret Medical Group

Morehead City, North Carolina, United States

Eastern Nephrology Associates, PLLC

New Bern, North Carolina, United States

Piedmont Healthcare/Research

Statesville, North Carolina, United States

Brookview Hills Research Associates, LLC

Winston-Salem, North Carolina, United States

Lillestol Research LLC

Fargo, North Dakota, United States

Cleveland Clinic - Main Campus

Cleveland, Ohio, United States

Providence Health Partners Ctr

Dayton, Ohio, United States

Ohio- Advanced Medical Research

Maumee, Ohio, United States

Heritage Valley Medical Group

Beaver, Pennsylvania, United States

Capital Area Research LLC

Newport, Pennsylvania, United States

Aria Endocrine Metabolic Assoc

Philadelphia, Pennsylvania, United States

Carolina Health Specialists

Myrtle Beach, South Carolina, United States

Univ Diab & Endo Consultants

Chattanooga, Tennessee, United States

PharmaTex Research

Amarillo, Texas, United States

Arlington Family Res. Ctr Inc

Arlington, Texas, United States

South Texas Clinical Research

Corpus Christi, Texas, United States

Baylor Scott & White Res Inst

Dallas, Texas, United States

Velocity Clinical Res-Dallas

Dallas, Texas, United States

Dallas Heart and Vascular

Duncanville, Texas, United States

Academy of Diabetes, T&E

El Paso, Texas, United States

Diabetes and Thyroid Ctr of FW

Fort Worth, Texas, United States

Forefront Med Res Inst PLLC

Harlingen, Texas, United States

PrimeCare Medical Group

Houston, Texas, United States

Synergy Groups Medical

Houston, Texas, United States

Southwest Houston Research Ltd

Houston, Texas, United States

Prem Internal Med Asso Houston

Katy, Texas, United States

Radiance Clinical Research

Lampasas, Texas, United States

DCOL Ctr for Clin Res

Longview, Texas, United States

Texas Inst, Kdny & Endo Disor

Lufkin, Texas, United States

Texas Institute of Cardiology PA

McKinney, Texas, United States

Texas Diabetes & Endocrinology_Round Rock

Round Rock, Texas, United States

Univ Of Texas Hlth Science Cntr

San Antonio, Texas, United States

Clinical Advancement Center

San Antonio, Texas, United States

San Antonio Prem Int Med

San Antonio, Texas, United States

Audie L. Murphy VA Hospital

San Antonio, Texas, United States

Northeast Clinical Research of San Antonio

San Antonio, Texas, United States

Simcare Medical Research, LLC

Sugar Land, Texas, United States

Crossroads Clinical Res- Texas

Victoria, Texas, United States

Hillcrest Family Health Center

Waco, Texas, United States

Valley Diab. & Endo Comp Ctr

Weslaco, Texas, United States

York Clinical Research LLC

Norfolk, Virginia, United States

Dominion Medical Associates

Richmond, Virginia, United States

VA Medical Center_Salem

Salem, Virginia, United States

Selma Medical Associates

Winchester, Virginia, United States

Confluence Health Hospital

Wenatchee, Washington, United States

Aspirus Research Institute

Wausau, Wisconsin, United States

Mautalen Salud e investigación

CABA, Buenos Aires, Argentina

CEMEDIC

CABA, Buenos Aires, Argentina

Hospital Italiano de la Plata

La Plata, Buenos Aires, Argentina

Instituto Medico Catamarca

Rosario, Santa Fe Province, Argentina

CIPREC Pueyrredon

Buenos Aires, Argentina

Centro Medico Dra. Laura Maffei e Investigacion Clínica Apli

Buenos Aires, Argentina

CEDIC Centro de Investigación Clínica

CABA, Argentina

Centro de Investigación y Prevención Cardiovascular

CABA, Argentina

CENUDIAB Centro Médico de Nutrición v Diabetes

CABA, Argentina

Medical Center of Diabetes and Nutrition

CABA, Argentina

Centro de Investigaciones Metabólicas

Capital Federal, Argentina

Instituto Médico DAMIC

Córdoba, Argentina

Centro Médico Privado San Vicente Diabetes

Córdoba, Argentina

Instituto de Investigaciones Clinicas Mar Del Plata

Mar del Plata, Argentina

Consultorio Integral de Atención al Diabético

Morón, Argentina

Instituto de Investigaciones Clinicas San Nicolás

San Nicolás, Argentina

Sanatorio Norte

Santiago del Estero, Argentina

Gosford Renal Research

Gosford, New South Wales, Australia

Paratus Clinical

Kanwal, New South Wales, Australia

Southern Neurology

Kogarah, New South Wales, Australia

Liverpool Hospital

Liverpool, New South Wales, Australia

Macquarie University - Clinical Trials Unit

Macquarie Park, New South Wales, Australia

Advara HeartCare Auchenflower

Auchenflower, Queensland, Australia

Logan Hospital

Meadowbrook, Queensland, Australia

Nightingale Research

Adelaide, South Australia, Australia

Royal Adelaide Hospital - Cardiology Department

Adelaide, South Australia, Australia

Advara HeartCare Leabrook

Leabrook, South Australia, Australia

Royal Hobart Hospital

Hobart, Tasmania, Australia

Baker Heart and Diabetes Institute

Melbourne, Victoria, Australia

Advara HeartCare Joondalup

Joondalup, Western Australia, Australia

One Clinical Research

Nedlands, Western Australia, Australia

Clinitrials

Perth, Western Australia, Australia

CPHosp Manaus Medicina, Ensino e Pesquisa LTDA

Manaus, Amazonas, Brazil

Centro de Pesquisa em Diabetes Doenças Endócrino-Metabólicas

Fortaleza, Ceará, Brazil

Centro de Diag. e Pesquisa da Osteoporose do Espírito Santo

Vitória, Espírito Santo, Brazil

Núcleo de Pesquisa Clínica S/S

Curitiba, Paraná, Brazil

Núcleo de Pesquisa Clínica do Rio Grande do Sul Ltda.

Porto Alegre, Rio Grande do Sul, Brazil

Instituto de Pesquisa Clínica de Campinas

Campinas, São Paulo, Brazil

PUCCAMP - Hospital e Maternidade Celso Pierro

Campinas, São Paulo, Brazil

i9 Pesquisas Clínicas

Campinas, São Paulo, Brazil

CIP Centro Integrado de Pesquisas do Hospital de Base

São José do Rio Preto, São Paulo, Brazil

Instituto São José dos Campos em Pesquisas Médicas

São José dos Campos, São Paulo, Brazil

Instituto de Pesquisa Clinica (IPEC)

São Paulo, São Paulo, Brazil

CPQuali Pesquisa Clínica Ltda

São Paulo, São Paulo, Brazil

CPCLIN - Centro de Pesquisas Clínicas

São Paulo, São Paulo, Brazil

Hospital São Lucas Copacabana

Rio de Janeiro, Brazil

CEPIC - Centro Paulista de Investigacao Clinica

São Paulo, Brazil

Medical centre Asclepius OOD

Dupnitsa, Kyustendil, Bulgaria

SRH - Zdrave EAD

Bankya, Bulgaria

DCC - Burgas EOOD

Burgas, Bulgaria

IPSOMC - Dr. Georgi Marinov

Burgas, Bulgaria

MC Diamedical - 2013 OOD, Dimitrovgrad

Dimitrovgrad, Bulgaria

AIPSMC - DiMed EOOD

Haskovo, Bulgaria

Medical centre Zdrave 1 OOD

Kozloduy, Bulgaria

MHAT - UniHospital OOD

Panagyurishte, Bulgaria

"MHAT - Pazardzhik"

Pazardzhik, Bulgaria

MHAT - Pazardzhik AD

Pazardzhik, Bulgaria

Medical center Medconsult Pleven OOD

Pleven, Bulgaria

OCSOMCE - Dr. Albena Dinkova EOOD

Pleven, Bulgaria

DCC Pulmed EOOD

Plovdiv, Bulgaria

MHAT Med Line Clinic

Plovdiv, Bulgaria

UMHAT Kaspela EOOD, Endocrinology and Metabolic Diseases Clinic

Plovdiv, Bulgaria

UMHAT - Plovdiv AD

Plovdiv, Bulgaria

UMHAT Pulmed OOD - Plovdiv, Department of Endocrinology

Plovdiv, Bulgaria

MHAT Sveta Karidad EAD

Plovdiv, Bulgaria

UMHAT Medica - Ruse OOD

Rousse, Bulgaria

AIPSOMCIDEMD - Dr. Lilyana Bodurova-Troharova EOOD

Samokov, Bulgaria

MHAT Dr. Ivan Seliminski - Sliven AD

Sliven, Bulgaria

Nader Yabrudi - ASMPVBE Individual practice

Smolyan, Bulgaria

MHAT Knyaginya Klementina - Sofia EAD

Sofia, Bulgaria

MHAT Sveta Sofia EOOD

Sofia, Bulgaria

Acibadem City Clinic UMHAT Tokuda EAD, Endocrinology

Sofia, Bulgaria

UMHAT Aleksandrovska EAD, Clinic of Endocrinology and Metabolic Diseases

Sofia, Bulgaria

UMHAT Sveti Ivan Rilski EAD, Nephrology

Sofia, Bulgaria

MC Orthopaedic Center Kinov EOOD

Sofia, Bulgaria

Medical Institute of Ministry of interior

Sofia, Bulgaria

MC Diamedical - 2013 OOD, Sofia

Sofia, Bulgaria

Medical centre Vitclinic EOOD

Sofia, Bulgaria

MBAL Trakia EOOD

Stara Zagora, Bulgaria

Medical center Zara-Med EOOD

Stara Zagora, Bulgaria

Prevencia - 2000 - MCOC OOD

Stara Zagora, Bulgaria

Medical Center Nov Rehabilitatsionen center EOOD

Stara Zagora, Bulgaria

UMHAT Prof. Dr. Stoyan Kirkovich AD

Stara Zagora, Bulgaria

UMHAT Sveta Marina EAD, Clinic of Internal Diseases

Varna, Bulgaria

UMHAT Sveta Marina EAD

Varna, Bulgaria

DCC 1 Velingrad EOOD

Velingrad, Bulgaria

Medical centre Runkovi OOD

Yambol, Bulgaria

MHAT Sveti Panteleimon - Yambol AD

Yambol, Bulgaria

Centricity Research Calgary Endocrinology

Calgary, Alberta, Canada

Centricity Research Calgary

Calgary, Alberta, Canada

C-endo Diab Endo Clin Calgery

Calgary, Alberta, Canada

C-Health Partners

Calgary, Alberta, Canada

G.A. Research Associates Ltd.

Moncton, New Brunswick, Canada

Nova Scotia Health Authority

Halifax, Nova Scotia, Canada

Centricity Res. Barrie Endo

Barrie, Ontario, Canada

Centricity Research Brampton Endocrinology

Brampton, Ontario, Canada

Cambridge Cardiac Care Centre

Cambridge, Ontario, Canada

Wharton Med Clin Trials

Hamilton, Ontario, Canada

Premier Clinical Trial Research Network (PCTRN)

Hamilton, Ontario, Canada

Diabetes Heart Research Centre

Toronto, Ontario, Canada

Clinical Research Solutions Inc.

Waterloo, Ontario, Canada

Ctr de recherche Clinique de Laval

Laval, Quebec, Canada

Manna Research Mirabel

Mirabel, Quebec, Canada

Applied Medical Informatics Research

Montreal, Quebec, Canada

Clin des Mal Lipid de Quebec

Québec, Quebec, Canada

Viacar Recherche Clinique Inc.

Saint-Lambert, Quebec, Canada

CHU-Sherbrooke

Sherbrooke, Quebec, Canada

Ctr de méd métab de Lanaudière

Terrebonne, Quebec, Canada

Recherche Clinique Sigma Inc.

Québec, Canada

Institut universitaire de cardiologie

Québec, Canada

Diex Recherche Quebec

Québec, Canada

Servicios de Salud Ips Suramericana S.A.S.

Medellín, Antioquia, Colombia

Clinica de la Costa

Barranquilla, Atlántico, Colombia

Fundación Hospital Universidad del Norte

Soledad, Barranquilla, Colombia

Unidad de Estudios Clínicos de la Fundación Cardiovascular de Colombia

Bucaramanga-piedecuesta, Valle Del Menzuli - Santander, Santander Department, Colombia

FOSCAL

Floridablanca, Santander Department, Colombia

Fundacion del Caribe para la Investigacion Biomedica-BIOS

Barranquilla, Colombia

CentrodeInvestigaciónenReumatologíayEspecialidadesMédicas

Bogotá, Colombia

Somer Sociedad Medica Rionegro S.A. Somer S.A.

Rionegro, Colombia

Herlev Hospital - Afdeling for Hjertesygdomme, Forskning 1

Herlev, Capital Region, Denmark

Aarhus Universitetshospital, Hjertesygdomme

Aarhus N, Central Jutland, Denmark

Holbæk Sygehus - Forskningsenheden, Medicinsk Afdeling, afs. 44-4

Holbæk, Region Sjælland, Denmark

Svendborg Sygehus - Kardiologisk

Svendborg, Region South, Denmark

Aarhus Universitetshospital, Steno Diabetes Center Aarhus

Aarhus N, Denmark

Regionshospitalet Gødstrup, Hjertesygdomme

Herning, Denmark

Hillerød Endokrinologisk amb. H0652

Hillerød, Denmark

Kolding Sygehus Karkirurgi

Kolding, Denmark

Slagelse Sygehus Ambulatorium for hjertesygdomme

Slagelse, Denmark

Viborg Sygehus

Viborg, Denmark

Centre Hospitalier d'Annonay

Annonay, France

Centre Hospitalier Ardeche Nord

Annonay, France

Ap-Hp-Hopital Avicenne

Bobigny, France

Centre Hospitalier Universitaire Grenoble Alpes-Site Nord Michallon-2

Grenoble, France

CH Louis Pasteur

Le Coudray, France

Les Hopitaux de Chartres-Hopital Louis Pasteur

Le Coudray, France

Groupe Hospitalier Du Havre

Le Havre, France

Centre Hospitalier Universitaire de Lille-Hopital Claude Huriez

Lille, France

Centre Hospitalier Universitaire de Montpellier-Hopital Lapeyronie

Montpellier, France

Aphp-Hopital La Pitie Salpetriere-2

Paris, France

Hopital Novo

Pontoise, France

Centre Hospitalier Bretagne Atlantique

Vannes, France

Centre de Recherche Clinique Portes Du Sud

Vénissieux, France

RESEAU DE SANTE MUTUALISTE-Médipôle Hôpital Mutualiste

Villeurbanne, France

Diabeteszentrum-Do Dres. K U. Ch. Busch GbR

Dortmund, Germany

Uniklinik TU Dresden - Med. Klinik III

Dresden, Germany

Zentrum fuer klinische Studien Suedbrandenburg GmbH

Elsterwerda, Germany

InnoDiab Forschung GmbH

Essen, Germany

MVZ CCB Frankfurt und Main-Taunus GbR

Frankfurt, Germany

Diabetes-Zentrum Wilhelmsburg

Hamburg, Germany

Diabetes-Zentrum-Wilhelmsburg GbR

Hamburg, Germany

Wendisch - Dahl Hamburg - DZHW

Hamburg, Germany

Uniklinik Heidelberg - Innere Medizin I

Heidelberg, Germany

Universitätsklinikum Leipzig - Klinik und Poliklinik für Kardiologie

Leipzig, Germany

AmBeNet GmbH

Leipzig, Germany

Diabeteszentrum Ludwigsburg

Ludwigsburg, Germany

Institut für Diabetesforschung GmbH Münster - Dr. med. Rose

Münster, Germany

Uniklinik Münster, Klinik für Kardiologie I

Münster, Germany

Universitätsklinikum Münster - Klinik für Kardiologie I

Münster, Germany

RED-Institut für medizinische Forschung und Fortbildung GmbH

Oldenburg in Holstein, Germany

Zentrum für klinische Studien Alexander Segner

Saint Ingbert-Oberwürzbach, Germany

Al-Zoebi

Wermsdorf, Germany

Forschungszentrum Ruhr KliFoCenter GmbH, Kahrmann

Witten, Germany

Endolife Specialty Hospitals

Guntur, Andhra Pradesh, India

Lalitha PVS Institute of Medical Sciences

Guntur, Andhra Pradesh, India

Lalitha Super Specialities Hospital

Guntur, Andhra Pradesh, India

Ramdev Rao Hospital

Hyderabad, Andhra Pradesh, India

Sunrise Hospital

Vijayawada, Andhra Pradesh, India

Excelcare Hospital

Guwahati, Assam, India

SMC Heart Institute and IVF Research Centre

Raipur, Chhattisgarh, India

SMC Heart Institute and IVF Research Centre

Raipur, Chhattisgarh, India

CIMS- Care Institute of Medical Sciences

Ahmedabad, Gujarat, India

Unicare heart institute and research centre

Surat, Gujarat, India

Nirmal Hospital Pvt. Ltd.

Surat, Gujarat, India

SSG Hospital, Baroda

Vadodara, Gujarat, India

Bankers Heart Institute

Vadodara, Gujarat, India

Rhythm Heart Institute

Vadodara, Gujarat, India

Ramaiah Memorial Hospital

Bangalore, Karnataka, India

Lifecare Hospital and Research Centre

Bangalore, Karnataka, India

Narayana Hrudayalya Institute of Cardiac Sciences

Bangalore, Karnataka, India

Omega Hospital (P) Limited

Mangalore, Karnataka, India

Mysore Medical College and Research Institute

Mysore, Karnataka, India

Government Medical College, Kozhikode

Kozhikode, Kerala, India

Mohak Bariatrics and Robotics

Indore, Madhya Pradesh, India

Kamalnayan Bajaj Hospital

Aurangabad, Maharashtra, India

Kamalnayan Bajaj Hospital

Aurangabad, Maharashtra, India

Krishna Institute of medical sciences

Karad, Maharashtra, India

Excel Endocrine Centre

Kolhāpur, Maharashtra, India

Sir H. N. Reliance Foundation Hospital and Research Centre

Mumbai, Maharashtra, India

Wockhardt Hospital, Mumbai Central

Mumbai, Maharashtra, India

Seth GS Medical College & KEM Hospital

Mumbai, Maharashtra, India

Hrudaya Cardiac and Vascular Care Centre

Nagpur, Maharashtra, India

Sengupta Hospital and Research Institute

Nagpur, Maharashtra, India

All India Institute of Medical Sciences (AIIMS), Nagpur

Nagpur, Maharashtra, India

Shalini Tai Meghe Hospital and Research Center

Nagpur, Maharashtra, India

Magnum Heart Institute

Nashik, Maharashtra, India

Grant Medical Foundation Ruby Hall Clinic

Pune, Maharashtra, India

Chellaram Diabetes Institute

Pune, Maharashtra, India

Ashirwad Hospital and Research Centre

Thane, Maharashtra, India

G B Pant Institute of Postgraduate Medical Education and Research

New Delhi, National Capital Territory of Delhi, India

All India Institute of Medical Sciences_Delhi

Ansārinagar, New Delhi, India

Apollo Hospital

Delhi, New Delhi, India

AMRI Hospital

Bhubaneswar, Odisha, India

All India Institute of Medical Sciences_Khurda

Khurda, Odisha, India

Christian Medical College and Hospital

Ludhiana, Punjab, India

Fortis Heart Institute and Multispeciality Hospital

Mohali, Punjab, India

Jawahar Lal Nehru Govt. Medical College

Ajmer, Rajasthan, India

SP Medical College

Bikaner, Rajasthan, India

SMS Medical College & Attached Hospitals

Jaipur, Rajasthan, India

Diabetes, Thyroid and Endocrine Centre

Jaipur, Rajasthan, India

All India Institute of Medical Sciences (AIIMS)

Jodhpur, Rajasthan, India

Madras Diabetes Research Foundation

Chennai, Tamil Nadu, India

Kg Hospital and Post Graduate Medical Institute

Coimbatore, Tamil Nadu, India

Christian Medical College Hospital, Vellore

Vellore, Tamil Nadu, India

Guru Nanak CARE Hospitals

Hyderabad, Telangana, India

AIG Hospitals,Hyderabad

Hyderabad, Telangana, India

Diabetes Research Center, Hyderabad

Hyderabad, Telangana, India

Yashoda Hospital

Hyderabad, Telangana, India

J N Medical College

Aligarh, Uttar Pradesh, India

King George's Medical University (KGMU)

Lucknow, Uttar Pradesh, India

Sanjay Gandhi Postgraduate Institute of Medical Sciences

Lucknow, Uttar Pradesh, India

Sanjay Gandhi Postgraduate Institute of Medical Science

Lucknow, Uttar Pradesh, India

Shri Mahant Indiresh Hospital

Dehradun, Uttarakhand, India

IPGME&R and SSKM Hospital

Kolkata, West Bengal, India

Apollo Multispeciality Hospital, Kolkata

Kolkata, West Bengal, India

J N Medical College

Aligarh, India

Narayana Hrudayalya Institute of Cardiac Sciences

Bangalore, India

Himachal Heart Institute

Gutkar, India

All India Institute of Medical Sciences (AIIMS)

Jodhpur, India

Krishna Institute of medical sciences

Karad, India

Diabetes Care N' Research Centre Pvt. Ltd.

Nagpur, India

Hrudaya Cardiac and Vascular Care Centre

Nagpur, India

Magnum Heart Institute

Nashik, India

G.B Pant Institute of Post Graduate medical education and research

New Delhi, India

BL Kapur Super Specialty Hospital

New Delhi, India

Dr. BL Kapur Memorial Hospital

New Delhi, India

Sir Ganga Ram Hospital

New Delhi, India

B J Medical College & Sassoon Hospital

Pune, India

WMF's Villoo Poonawalla Memorial Hospital

Pune, India

Citi neuro centre

Telangana, India

CRF - Galway

Galway, Connaght, Ireland

CRF HRB - Galway

Galway, Connaght, Ireland

Clinical Research Centre, St. Vincent's University Hospital,

Dublin, Leinster, Ireland

Mater Miscericordiae Hospital

Dublin, Leinster, Ireland

St James's CRF

Dublin, Leinster, Ireland

Connolly Hospital_Blanchardstown_Diabetes Day Centre

Dublin, Leinster, Ireland

Mater Miscericordiae Hospital

Dublin, Leinster, Ireland

Università degli studi G. D'Annunzio Chieti Pescara - CAST

Chieti, Abruzzo, Italy

A.O.U. Consorziale Policlinico di Bari

Bari, BA, Italy

Azienda Ospedaliero Universitaria di Modena

Modena, Emilia-Romagna, Italy

Azienda Ospedaliera-Universitaria Parma

Parma, Emilia-Romagna, Italy

Pol. Uni. Campus Biomedico - UOC Endocrinologia e Diabetologia

Rome, Lazio, Italy

Policlinico San Donato S.p.A.

San Donato Milanese (MI), Lombardy, Italy

Ospedale Santa Maria Goretti - UOD Diabetologia

Latina, LT, Italy

Centro di Alta Spec. Diet., Educ. Alim. e Prev. Cardio Metab

San Donato Milanese (MI), Mi, Italy

ICS Maugeri

Pavia, Pv, Italy

Fondazione Policlinico Universitario Agostino Gemelli IRCS

Rome, RM, Italy

AOUP Giaccone Palermo

Palermo, Sicily, Italy

Azienda Ospedaliera Universitaria Senese

Siena, Si, Italy

AOU Careggi Firenze

Florence, Tuscany, Italy

Azienda Ulss 3 Serenissima

Mirano, VE, Italy

Ente Ecclesiastico Ospedale Generale Regionale Miulli - Cardiologia e UTIC

Acquaviva delle Fonti, Italy

Azienda Ospedaliero Universitaria Ospedali Riuniti di Ancona

Ancona, Italy

A.O.U. Bologna_ Policlinico S.Orsola Malpighi

Bologna, Italy

A.O.U. Policlinico S.Orsola Malpighi

Bologna, Italy

A.O.U policlinico "G. Rodolico-San Marco"

Catania, Italy

Azienda Ospedaliera Luigi Sacco

Milan, Italy

Azienda Ospedaliero Universitaria di Modena Ospedale Civile di Baggiovara

Modena, Italy

Azienda Ospedaliera Universitaria Federico II di Napoli

Naples, Italy

Azienda Ospedaliero Universitaria Pisana

Pisa, Italy

Pol. Uni. Campus Biomedico UOC Endocrinologia e Diabetologia

Roma, Italy

Azienda Ospedaliero - Universitaria Sant'Andrea

Roma, Italy

IRCCS Multimedica

Sesto San Giovanni (MI), Italy

Seino Internal Medicine Clinic_Internal medicine

Koriyama-shi, Fukushima, Fukushima, Japan, Japan

Seino Internal Medicine Clinic

Koriyama-shi, Fukushima, Japan, Japan

Jinnouchi Hospital_Internal Medicine

Kumamoto, Kumamoto, Japan, Japan

Akaicho Clinic

Chiba-shi, Chiba, Japan

Mikannohana Clinic, Diabetes, Endocrinology and Metabolism_Diabetes Internal Medicine

Ehime, Japan

Naka Kinen Clinic_Internal medicine

Ibaraki, Japan

Tokyo Saiseikai Central Hospital

Minato-ku, Tokyo, Japan

Minami Akatsuka Clinic

Mito-shi, Ibaraki, Japan

Nanbu Tokushukai Hospital_Internal medicine

Okinawa, Japan

Osaka NISHI-UMEDA Clinic_Internal Medicine

Osaka, Japan

Nozaki Tokushukai Hospital_Internal medicine

Osaka, Japan

Yao Tokushukai General Hospital_Cardiovascular division

Osaka, Japan

Yao Tokushukai General Hospital

Osaka, Japan

Sakurabashi Watanabe Advanced Healthcare Hospital

Osaka-city, Osaka, Japan

Saga University Hospital, Department of Cardiology

Saga, Japan

Kagawa Prefectural Central Hospital_Cardiovascular Medicine

Takamatsu-shi, Kagawa, Japan

Takasaki General Medical Center_Department of Endocrinology / Metabolism Internal Medicine

Takasaki-shi, Gunma, Japan

Tokyo-Eki Center-building Clinic_Internal Medicine

Tokyo, Japan

Tokyo-Eki Center-building Clinic

Tokyo, Japan

Fukuwa Clinic_Internal Medicine

Tokyo, Japan

Japanese Red Cross Wakayama Medical Center_Diabetology and Endocrinology

Wakayama, Japan

National Hospital Organization Saitama Hospital_Cardiology

Wako-shi, Saitama, Japan

University Malaya Medical Centre

Lembah Pantai, Kuala Lumpur, Malaysia

Hospital Tengku Ampuan Afzan

Kuantan, Pahang, Malaysia

Hospital Sultan Haji Ahmad Shah

Temerluh, Pahang, Malaysia

Hospital Seri Manjung

Seri Manjung, Perak, Malaysia

Hospital Pulau Pinang

George Town, Pulau Pinang, Malaysia

Sarawak General Hospital

Kuching, Sarawak, Malaysia

Hospital Miri

Miri, Sarawak, Malaysia

Hospital Sibu

Sibu, Sarawak, Malaysia

Hospital Ampang

Ampang, Selangor, Malaysia

Hospital Serdang

Kajang, Selangor, Malaysia

Hospital Melaka

Malacca, Malaysia

Hospital Putrajaya

Putrajaya, Malaysia

Hospital Miri

Sarawak, Malaysia

Hospital Ampang

Selangor Darul Ehsan, Malaysia

Hospital Shah Alam

Shah Alam, Malaysia

Hospital Putrajaya

Wilayah Persekutuan Putrajaya, Malaysia

Centro de Investigacion Clinica Endocrinologica de Jalisco

Guadalajara, Jalisco, Mexico

Virgen Cardiovascular Research SC

Guadalajara, Jalisco, Mexico

Instituto de Diabetes Obesidad y Nutricion S.C.

Cuernavaca, Morelos, Mexico

Internal Medicine Clin Trials

Monterrey, Nuevo León, Mexico

Cardiolink Clin Trials S.C.

Monterrey, Nuevo León, Mexico

Unidad Biomedica Avanzada Monterrey

Monterrey, Nuevo León, Mexico

Clínica García Flores

Monterrey, Nuevo León, Mexico

Centro de atención e investigación cardiovascular del Potosí

San Luis Potosí City, San Luis Potosí, Mexico

Centro para el Desarrollo de la Medicina y de Asistencia Médica Especializada, S.C.

Culiacán, Sinaloa, Mexico

Centro para el Desarrollo de la Medicina y la Asistencia

Culiacán, Sinaloa, Mexico

Centro de Estudios de Investigación Metabólicos y Cardio

Ciudad Madero, Tamaulipas, Mexico

Consultorio 1020 Hospital Angeles Xalapa

Xalapa, Veracruz, Mexico

Promotora Medica Aguascalientes SA de CV

Aguascalientes, Mexico

Gelre Zkh Apeldoorn Cardiologie

Apeldoorn, Netherlands

Maxima MC Eindhoven - Cardiologie

Eindhoven, Netherlands

Groene Hart Zkh Gouda - Cardiologie

Gouda, Netherlands

UMC Groningen - Cardiologie

Groningen, Netherlands

Frisius MC Leeuwarden

Leeuwarden, Netherlands

Radboudumc

Nijmegen, Netherlands

Franciscus Gasthuis en Vlietland

Rotterdam, Netherlands

D & A Research B.V.

Sneek, Netherlands

Zkh Rivierenland Tiel - Cardiologie

Tiel, Netherlands

NSZOZ Unica CR

Dąbrówka, Greater Poland Voivodeship, Poland

Gierach-Med

Bygdoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Malopolskie Centrum Sercowo-Naczyniowe

Chrzanów, Lesser Poland Voivodeship, Poland

Med. Cent. Diabet. Endo. Metabol. DIAB-ENDO-MET

Krakow, Lesser Poland Voivodeship, Poland

Regionalna Poradnia Diabetologiczna-Zytkiewicz-Jaruga, Stasinska Spolka Partnerska Lekarzy

Wroclaw, Lower Silesian Province, Poland

4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu

Wroclaw, Lower Silesian Voivodeship, Poland

4 Wojskowy Szpital Kliniczny Z Poliklinika Samodzielny Publiczny Zaklad Opieki Zdrowotnej We Wroclawiu

Wroclaw, Lower Silesian Voivodeship, Poland

Velocity Nova Sp. z o.o.

Lublin, Lublin Voivodeship, Poland

ETG Poniatowa

Poniatowa, Lublin Voivodeship, Poland

Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski

Gorzów Wielkopolski, Lubusz Voivodeship, Poland

Provita Poliklinika Sp. z o.o

Warsaw, Masovian Province, Poland

MEDI CLINICAL Badania Kliniczne

Warsaw, Masovian Province, Poland

Samodzielny Publiczny Szpital Kliniczny Im. Prof. W. Orlowskiego Centrum Medycznego Ksztalcenia Podyplomowego

Warsaw, Masovian Voivodeship, Poland

Samodzielny Publiczny Szpital Kliniczny Im. Prof. W. Orłowskiego Centrum Medycznego Kształcenia Podyplomowego

Warsaw, Masovian Voivodeship, Poland

ETG Warszawa Sp. z o.o.

Warsaw, Masovian Voivodeship, Poland

Prywatna Praktyka Lekarska Anna Chudoba

Żyrardów, Masovian Voivodeship, Poland

Uniwersytecki Szpital Kliniczny w Bialymstoku K. Kardio

Bialystok, Podlaskie Voivodeship, Poland

Gabinet Leczenia Otylosci i Chorob Dietozaleznych

Bialystok, Podlaskie Voivodeship, Poland

Kresmed Sp. z o. o.

Bialystok, Podlaskie Voivodeship, Poland

Centrum Medyczne Pratia Gdynia

Gdynia, Pomeranian Voivodeship, Poland

M2M Med. Badania Sp. z o.o.

Chorzów, Silesian Voivodeship, Poland

Kardio Klinika Brynow

Katowice, Silesian Voivodeship, Poland

Pro Familia Altera Sp. z o.o.

Katowice, Silesian Voivodeship, Poland

Slaskie Centrum Chorob Serca W Zabrzu

Zabrze, Silesian Voivodeship, Poland

Wojewodzka Poradnia dla Chorych na Cukrzyce w Zabrzu

Zabrze, Silesian Voivodeship, Poland

Centrum Zdrowia Metabolicznego

Poznan, Wielkopolskie Voivodeship, Poland

Osteo-Medic s.c. A. Racewicz, J. Supronik

Bialystok, Poland

Renew Clinic Sp. z o.o.

Bialystok, Poland

American Heart of Poland S.A.

Bielsko-Biala, Poland

Centrum Medyczne Kermed Renata Bijata-Bronisz I Ewa Kowalinska Sp. j.

Bydgoszcz, Poland

Pratia S.A.

Chojnice, Poland

NSZOZ Unica CR

Dąbrówka, Poland

Centrum Kliniczno Badawcze

Elblag, Poland

UCK Klinika Nadcisnienia Tetniczego i Diabetologii

Gdansk, Poland

Specjalistyczny Gabinet Diabetologiczny Radoslaw Rumianowski

Gorzów Wielkopolski, Poland

Care Clinic Sp. z o. o.

Katowice, Poland

Uniwersyteckie Centrum Kliniczne SUM w Katowicach

Katowice, Poland

Grazyna Pulka Specjalistyczny Osrodek "All-Med"

Krakow, Poland

Gabinet Lekarski Malgorzata Saryusz-Wolska

Lodz, Poland

Centralny Szpital Kliniczny Uniwersytetu Medycznego w Lodzi

Lodz, Poland

Zanamed Medical Clinic Sp. z o.o.

Lublin, Poland

Provita Centrum Medyczne Sp. z o.o.

Piotrkow Trybunalski, Poland

Gaja Poradnie Lekarskie

Poznan, Poland

Niepubliczny Zaklad Opieki Zdrowotnej Przychodnia Specjalistyczna A Wittek H Rudzki Sp. j.

Ruda Śląska, Poland

Polsko - Amerykanskie Kliniki Serca X Oddzial Kardiologii Inwazyjnej, Elektrofizjologii i Elektrostymulacji w Tychach

Tychy, Poland

Szpital Czerniakowski Sp. z o.o.

Warsaw, Poland

BodyClinic

Warsaw, Poland

NASMED

Warsaw, Poland

Pracownia Badan Klinicznych SALUS

Wroclaw, Poland

Wojewodzka Poradnia dla Chorych na Cukrzyce w Zabrzu

Zabrze, Poland

Velocity Nova Sp. z o.o. Velocity Zamosc

Zamość, Poland

Szpitale Powiatowe Sp. z o.o.

Łask, Poland

American Heart of Poland S.A.

Bełchatów, Łódź Voivodeship, Poland

Wojewodzkie Wielospecjalistyczne Centrum Onkologii i Traumatologii im. M. Kopernika

Lodz, Łódź Voivodeship, Poland

Velocity Nova Sp. z o.o.

Staszów, Świętokrzyskie Voivodeship, Poland

Isis Clinical Res. Ctr P.S.C.

Guaynabo, Puerto Rico

University Clinical Centre Nis

Niš, RS, Serbia

Clinical Centre Nis, Endocrinology, Diabetes and Metabolism

Niš, RS, Serbia

Clin. Centre Vojvodina, Clin. endocr., diab. and met. dis.

Novi Sad, Vojvodina, Serbia

CHC Zvezdara, Clinical department for endocrinology

Belgrade, Serbia

Endocrinology, Diabetes and Metabolism Diseases Clinic

Belgrade, Serbia

Military Medical Academy

Belgrade, Serbia

Clinical Hospital Center Bezanijska Kosa

Belgrade, Serbia

Clinical Centre Kragujevac, Internal Diseases Clinic, Endocrinology department

Kragujevac, Serbia

Policlinic for diabetes

Zaječar, Serbia

Phoenix Pharma

Port Elizabeth, Eastern Cape, South Africa

Soweto Clinical Trial Centre

Johannesburg, Gauteng, South Africa

Hemant Makan

Johannesburg, Gauteng, South Africa

Wits Bara Clinical Trial Site

Johannesburg, Gauteng, South Africa

Ezintsha Research Centre

Johannesburg, Gauteng, South Africa

Prinshof Medical Campus