Clinical Research Directory

Inclusion Criteria: An individual who meets any of the following criteria can be eligible for participation in this study: 1. Child or adult 2. Written informed consent 3. Suspected or confirmed disease with systemic inflammation (acute, chronic and/or recurrent), these include: 1. Autoinflammatory diseases (AID), including among others: systemic onset juvenile idiopathic arthritis (sJIA), familial mediterranean fever (FMF), mevalonate kinase deficiency (Hyper IgD syndrome), TNF receptor-associated periodic syndrome (TRAPS), familial Cold Autoinflammatory Syndrome (CAPS), type 1 interferonopathies,… 2. Autoimmune diseases (AI), including among others: systemic lupus erythematosus (SLE), juvenile dermatomyositis (JDM), rheumatoid arthritis (RA),… 3. Hyperinflammatory diseases, including among others: hemophagocytic lymphohistiocytosis (HLH), macrophage activation syndrome (MAS), infection-related cytokine storm (e.g. in the setting of COVID-19) 4. Other unidentified or not yet identified systemic inflammatory conditions 4. Blood sample for diagnostic purposes is planned and possibility to acquire additional blood volume Exclusion Criteria: An individual who meets any of the following criteria will be excluded from participation in this study: 1. Confirmed localized infection and/or good response to first-line antibiotic treatment 2. Confirmed malignancy Besides the above mentioned patients, volunteers that meet the requirements as a healthy individual are eligible for inclusion as controls.