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Preoperative Boost Associated With Neoadjuvant Chemotherapy in Luminal B Breast Cancer
Sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Summary
IBISCO TRIAL is a phase II trial aimed to demonstrate the improvement of pathological complete response (pCR) in Luminal B breast cancer (BC) patients treated with stereotactic radiation therapy (SBRT) as an anticipated boost associated with neoadjuvant chemotherapy (NAC). As a secondary objective, histochemical and molecular analysis of the tumour and the inflammatory microenvironment will be performed.
Official title: Immune and Pathological Response in Breast Cancer After Preoperative Irradiation With Stereotactic Technique and Neoadjuvant ChemOtherapy
Key Details
Gender
FEMALE
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2023-05-24
Completion Date
2027-12-31
Last Updated
2024-12-18
Healthy Volunteers
No
Conditions
Interventions
SBRT anticipated boost
24 Gy in 3 fractions to the tumour
Locations (1)
IRCCS Azienda Ospedaliero-Universitaria di Bologna
Bologna, Italy