Clinical Research Directory
Browse clinical research sites, groups, and studies.
International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery
Sponsor: Children's Hospital of Philadelphia
Summary
The goal of this observational study is to determine the incidence of perioperative cerebral desaturation in neonates undergoing surgery for congenital malformations. The main questions it aims to answer are: 1. The perioperative factors associated with occurrence of cerebral desaturation 2. The association between perioperative cerebral desaturation, perioperative/hospital outcomes, and physiological conditions. Participants will undergo Near-infrared spectroscopy (NIRS) and electroencephalogram (EEG) monitoring for one hour before surgery, during surgery, and up to 24 hours after surgery.
Key Details
Gender
All
Age Range
Any - 60 Weeks
Study Type
OBSERVATIONAL
Enrollment
900
Start Date
2022-08-12
Completion Date
2027-12-31
Last Updated
2025-04-17
Healthy Volunteers
Not specified
Interventions
NIRS/EEG monitoring
The study intervention will be monitoring NIRS and EEG for one hour before surgery, during surgery, and up to 8-24 hours after surgery.
Locations (15)
Children's Hospital at Montefiore/Albert Einstein College of Medicine
New York, New York, United States
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States
Children's Medical Center Dallas
Dallas, Texas, United States
Children's Memorial Hermann Hospital
Houston, Texas, United States
Perth Children's Hospital
Nedlands, Australia
Royal Children's Hospital
Parkville, Australia
Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo
São Paulo, Brazil
Guangzhou women and children's medical center
Guangzhou, China
Shanghai Children's Medical Center
Shanghai, China
Shengjing Hospital of China Medical University
Shenyang, China
West China Hospital and West China Second University Hospital
Sichuan, China
Centre Hospitalier Universitaire de Bordeaux, Hopital des enfants
Bordeaux, France
Post Graduate Institute of Medical Education and Research
Chandigarh, India
Christian Medical College Hospital
Vellore, India
Great Ormond Street Hospital for Children
London, United Kingdom