Clinical Research Directory

Inclusion Criteria * Clinical diagnosis of generalized onset or focal epilepsy or sleep-related epileptic encephalopathy. * Estimated to have at least 2 countable seizures per month or spike-wave index ≥50%. * Has not had control with at least 2 anti-seizure medicines. * Able to maintain a constant medication for duration of the study (rescue meds allowed). * Subject or legally authorized representative is able to understand consent and keep a seizure diary in English. Exclusion Criteria: * A disease likely to progress over course of the study. * Psychogenic non-epileptic seizures. * Suicide attempt or psychiatric hospitalization past 2 years. * A skin condition interfering with scalp electrodes or allergy to silver. * Women will verify not pregnant, and if applicable, have a serum pregnancy test. * Implanted devices (e.g. pacemakers)-except VNS, which is allowed.