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The Impact of Preoperative Olanzapine on Quality of Recovery After Discharge From Ambulatory Surgery
Sponsor: Yale University
Summary
The primary objective of this phase 2 randomized controlled trial is to determine whether the pre-operative administration of olanzapine (5 mg PO) improves quality of recovery (assessed by the Quality of Recovery-40 (QoR-40) survey) on postoperative day 1 in patients having ambulatory surgery with general anesthesia. The secondary objectives of this study are to determine whether there are differences in quality of recovery on postoperative day 2, presence of post-discharge nausea, presence of severe post-discharge nausea, recovery room length of stay and opioid consumption in patients who receive the study drug versus placebo.
Official title: The Impact of Pre-operative Olanzapine on Quality of Recovery-40 Scores After Discharge From Ambulatory Surgery
Key Details
Gender
FEMALE
Age Range
18 Years - 50 Years
Study Type
INTERVENTIONAL
Enrollment
398
Start Date
2023-06-26
Completion Date
2025-12-06
Last Updated
2026-07-16
Healthy Volunteers
No
Conditions
Interventions
Olanzapine
5 mg of oral olanzapine one hour prior to ambulatory surgery
Placebo
oral matched placebo one hour prior to ambulatory surgery
Locations (1)
Yale New Haven Hospital
New Haven, Connecticut, United States