Tundra Space

Tundra Space

Clinical Research Directory

Browse clinical research sites, groups, and studies.

Back to Studies
COMPLETED
NCT05676294
PHASE2

The Impact of Preoperative Olanzapine on Quality of Recovery After Discharge From Ambulatory Surgery

Sponsor: Yale University

View on ClinicalTrials.gov

Summary

The primary objective of this phase 2 randomized controlled trial is to determine whether the pre-operative administration of olanzapine (5 mg PO) improves quality of recovery (assessed by the Quality of Recovery-40 (QoR-40) survey) on postoperative day 1 in patients having ambulatory surgery with general anesthesia. The secondary objectives of this study are to determine whether there are differences in quality of recovery on postoperative day 2, presence of post-discharge nausea, presence of severe post-discharge nausea, recovery room length of stay and opioid consumption in patients who receive the study drug versus placebo.

Official title: The Impact of Pre-operative Olanzapine on Quality of Recovery-40 Scores After Discharge From Ambulatory Surgery

Key Details

Gender

FEMALE

Age Range

18 Years - 50 Years

Study Type

INTERVENTIONAL

Enrollment

398

Start Date

2023-06-26

Completion Date

2025-12-06

Last Updated

2026-07-16

Healthy Volunteers

No

Interventions

DRUG

Olanzapine

5 mg of oral olanzapine one hour prior to ambulatory surgery

DRUG

Placebo

oral matched placebo one hour prior to ambulatory surgery

Locations (1)

Yale New Haven Hospital

New Haven, Connecticut, United States