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Pain, Central Sensitization and Psychoemotional State in Patients With Chronic Masticatory Muscle Pain
Sponsor: Wroclaw Medical University
Summary
The aim of this study is to investigate the relationship of psychological aspects, selected blood parameters, pain, central sensitization, and muscle electromyography activity in patients with chronic masticatory muscle pain.
Official title: Assessment of the Relationship Between Pain, Central Sensitization and Psychoemotional State in Patients With Chronic Masticatory Muscle Pain
Key Details
Gender
All
Age Range
18 Years - 80 Years
Study Type
OBSERVATIONAL
Enrollment
102
Start Date
2023-09-01
Completion Date
2026-12
Last Updated
2026-02-03
Healthy Volunteers
Yes
Conditions
Interventions
Diagnostic Criteria for Temporomandibular Disorders Clinical Examination
Clinical examination made by experienced dentists (minimum 5 years of practice) and trained and calibrated in accordance with the protocol available on the DC/TMD.
Blood test
Blood samples will be tested to investigate two polymorphisms of genes encoding proteins for serotonin receptors HTR2A - rs4941573 in intron 3 and dopamine DRD3 - rs6280 (Ser9Gly) and levels of serotonin, dopamine, Gamma-aminobutyric acid (GABA), Tumor Necrosis Factor α (TNF-α), CGRP, SERT, interleukin 1B, interleukin 6, interleukin 8, interleukin 10 and interleukin 17A.
Locations (1)
Wroclaw Medical University
Wroclaw, Poland