Clinical Research Directory

Inclusion Criteria * Age between 50 and 70 years * Magnetic resonance imaging verified rotator cuff tear (within 6 month prior to surgery) * Rupture size with a maximum diameter of 3 cm * Willingness to participate in the study * Willingness to participate in a unified physiotherapy with use of a shoulder abduction pad for four weeks postoperativel Exclusion Criteria: * Patients younger than 50 or older than 70 years of age * Pregnancy * Known allergy to zoledronic acid or other components of the medicinal product * Previous fracture of the affected shoulder * Previous surgery of the affected shoulder * Previous or existing bacterial infection of the affected shoulder * Rupture of more than two tendons in the affected shoulder (massive rotator cuff tear) * Isolated subscapularis tendon tear * Presence of glenohumeral osteoarthritis (Hamada type 3 or higher) * Diabetes mellitus (fasting glucose ≥ 126 mg/dl, HbA1C ≥ ZORRO Version Draft1.0/09.05.2022 Page 6 of 42 6.5%) * Malignant tumor disease * Pathological dental status * Known disease that interferes with bone metabolism * Concomitant diseases that do not permit general anesthesia * Previous therapy with anti-osteoporotic drugs (bisphosphonates, denosumab, teriparatide) * Epilepsy * Claustrophobia * Chronic alcohol abuse * Drug abuse