Clinical Research Directory
Browse clinical research sites, groups, and studies.
The DANE-HEART Trial - Computed Tomography Coronary Angiography for Primary Prevention
Sponsor: Rigshospitalet, Denmark
Summary
The goal of this randomized controlled clinical trial in asymptomatic individuals with risk factors for cardiovascular disease is to investigate whether a preventive treatment strategy guided by computed tomography coronary angiography (CTCA) provides a patient-centered approach, which ensures optimal protection against serious cardiovascular disease. The main question it aims to answer is: Does preventive treatment guided by CTCA reduce the risk of heart attacks or cardiovascular death as compared to using conventional cardiovascular risk scores. Participants will be randomized to preventive medical therapy and/or invasive intervention guided by either CTCA (intervention group) or Systematic COronary Risk Evaluation (SCORE) 2 model for cardiovascular risk prediction (control group).
Official title: Prevention of Heart Disease in Adult Danes Using Computed Tomography Coronary Angiography - The DANE-HEART Trial
Key Details
Gender
All
Age Range
40 Years - Any
Study Type
INTERVENTIONAL
Enrollment
6000
Start Date
2023-03-20
Completion Date
2033-06
Last Updated
2023-03-22
Healthy Volunteers
No
Interventions
Primary preventive treatment guided by CTCA
Computed tomography coronary angiography (CTCA)
Cardiovascular risk Score
Systematic COronary Risk Evaluation 2 model for cardiovascular risk prediction
Locations (2)
Department of Cardiology and Radiology, Rigshospitalet, The Heart Center, Capital Region of Copenhagen, University of Copenhagen
Copenhagen, Denmark
The Copenhagen General Population Study, Herlev-Gentofte Hospital, University of Copenhagen, Denmark
Herlev, Denmark