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Fecal Microbiota Transplantation in Pediatric Ulcerative Colitis (UC)
Sponsor: Biao Zou
Summary
This study included two topics: one was to test the efficacy and safety of fecal microbiota transplants plus partial enteral nutrition (PEN) in refractory pediatric UC where conventional therapy has failed, and the other was to explore the efficacy and safety of FMT plus PEN as first-line therapy for pediatric active UC
Official title: Repeated and Multiple Fecal Microbiota Transplantations in Active Pediatric Ulcerative Colitis (UC)
Key Details
Gender
All
Age Range
2 Years - 16 Years
Study Type
INTERVENTIONAL
Enrollment
30
Start Date
2022-12-01
Completion Date
2025-06-30
Last Updated
2024-11-04
Healthy Volunteers
Yes
Conditions
Interventions
Fecal Microbiota Transplantation
In the induction stage of UC, FMT group received FMT and PEN intervention, and FMT group are given for at least one course of FMT treatment. If repeated FMTs are received, it is usually at a 2 month interval. All the participants received PEN (80% of total calories as a polymeric diet, Peptamen, Nestle, Vevey, and Switzerland) intervention to help induce and maintain clinical remission.
Locations (1)
Tongji Hospital
Wuhan, China