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Evaluation of the Effect of Systemic Proteolytic Enzyme Therapy on Postoperative Inflammatory Response and QoL After Surgical Extraction of Impacted Mandibular Third Molars
Sponsor: University of Baghdad
Summary
1. To compare the postoperative pain between the patients who receive the systemic enzyme therapy and patients in the control group in the third and seventh day. 2. To compare the postoperative swelling (edema) between the patients who receive the systemic enzyme therapy and patients in the control group in the third and seventh day. 3. To compare the degree of trismus between the patients who receive the systemic enzyme therapy and patients in the control group in the third and seventh day. 4. Measure patients' perceptions of changes in their quality of life in the postoperative period and compare it between the patients who receive the systemic enzyme therapy and patients in the control group in the third and seventh day.
Official title: Evaluation of the Effect of Systemic Proteolytic Enzyme Therapy on Postoperative Inflammatory Response and Quality of Life After Surgical Extraction of Impacted Mandibular Third Molars
Key Details
Gender
All
Age Range
18 Years - 40 Years
Study Type
INTERVENTIONAL
Enrollment
55
Start Date
2024-05-08
Completion Date
2024-09-09
Last Updated
2024-05-08
Healthy Volunteers
No
Conditions
Interventions
systemic proteolytic enzyme (Tibrolin)
Tibrolin is a fixed dose combination of(Trypsin 48 mg, Bromelain 90 mg) and a bioflavonoid (Rutoside 100 mg)
Amoxicillin 500mg+metronidazole 500mg+ doliprane 100mg
Amoxicillin is given with metronidazole 500mg 1\*3' Doliprane 1000mg is given 1\*1
Locations (1)
Dunya Abdulmuniem Mahmood
Baghdad, Iraq