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Functional and Structural Changes in the Central Nervous System Following Spinal Cord Injury
Sponsor: University of Zurich
Summary
Building on recent improvements, state-of-the-art functional MRI will be applied as an advanced diagnostic tool for the lumbosacral cord in spinal cord injury (SCI) patients to characterize the remaining neuronal activity of the motor and sensory neurons. Alterations in the activity pattern will reveal the effect upon task-related spinal cord activity of the lower motor neurons and sensory neurons undergoing trauma-induced neurodegeneration, at a spatial specificity that has not been possible so far. Results of this study will be of crucial importance because SCI patients can only profit from regeneration-inducing therapies if spinal neuronal function is preserved below the level of lesion.
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
OBSERVATIONAL
Enrollment
225
Start Date
2023-01-01
Completion Date
2027-08-31
Last Updated
2025-12-15
Healthy Volunteers
Yes
Locations (1)
Balgrist University Hospital
Zurich, Switzerland