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Stroke-induced Myocardial Dysfunction: Role of GDF-15 (SMOG-15) Clinical Work Package
Sponsor: Centre Hospitalier Universitaire Dijon
Summary
The aim of this study is to analyze the relationship between the blood biomarker GDF-15 and heart damage after stroke. It is being conducted in France, in the Neurology Department of the Dijon University Hospital (Burgundy). The research is interventional because a biological blood test will be performed, as well as a heart rhythm recording and several cardiac echograms during the hospitalization of the participants and during the follow-up consultation scheduled 4 to 6 months after the stroke. A total of 130 stroke patients will participate in this study. Participation includes 4 visits: * Inclusion visit (within 24 hours of the first stroke symptoms) * visit 1 (within 24 to 72 hours of stroke) * visit 2 (within 48 hours of visit 1) * Visit 3 (approximately 4-6 months post-stroke)
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
130
Start Date
2023-02-13
Completion Date
2027-08
Last Updated
2025-01-28
Healthy Volunteers
No
Conditions
Interventions
Electrocardiogram
Inclusion visit, V1, V2 and V3
transthoracic echocardiography
V1, V2 and V3
standard biology
Inclusion visit
determination of serum GDF-15, osteoprotegerin and ST-2
Inclusion visit, V1, V2 and V3
Ultrasensitive Troponin-Ic
Inclusion visit, V1, V2 and V3
Collection of clinical and radiological data
Inclusion visit, V1 and V3: clinical data only V2: clinical and radiological data
72-hour continuous Holter-ECG recording
V1
Locations (1)
Chu Dijon Bourgogne
Dijon, France