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Epicardial Radiofrequency Catheter Ablation in Patients With Brugada Syndrome: a Randomized, Sham-controlled, Masked Clinical Trial
Sponsor: University of Sao Paulo General Hospital
Summary
This randomized, sham-controlled, and blinded clinical trial aims to evaluate the effects of radiofrequency catheter ablation on the phenotypic expression of patients with Brugada syndrome. The main questions it seeks to address are: * What are the immediate effects of radiofrequency catheter ablation on cardiac electrophysiology? * Is substrate-directed radiofrequency catheter ablation safe for patients with Brugada syndrome? * Is substrate-directed epicardial radiofrequency catheter ablation effective in normalizing the electrocardiographic pattern and preventing life-threatening arrhythmic events? Researchers will compare the ablation group with the control group to determine if there are differences in clinical and invasive markers of the disease after one year of follow-up.
Official title: Electrophysiological and Clinical Effects of Subtrate-directed Epicardial Radiofrequency Catheter Ablation in Patients With Brugada Syndrome: a Randomized, Sham-controlled, Masked Clinical Trial
Key Details
Gender
All
Age Range
18 Years - 70 Years
Study Type
INTERVENTIONAL
Enrollment
20
Start Date
2020-11-03
Completion Date
2026-03
Last Updated
2026-03-23
Healthy Volunteers
No
Conditions
Interventions
Radiofrequency catheter ablation
Radiofrequency application via catheter to burn the electroanatomic substrate implicated in Brugada syndrome
Sham procedure
Venous and epicardial punctions, catheter insertions, programmed electrical stimulation and electroanatomical mapping
Locations (1)
Instituto do Coração - InCor - HC/FMUSP
São Paulo, São Paulo, Brazil