Clinical Research Directory

Inclusion Criteria: * PCD diagnosis with confirmation of 2 identified pathogenic genetic variants within 1 of the following ultrastructure variants: * DNAI1 ODA defect * Other ODA defect * IDA - MTD defect * RS defect * Informed consent Exclusion Criteria: * Are a current smoker (e-cigarette, tobacco, or marijuana) * Are a former smoker who discontinued smoking \<1 year prior to enrollment or has a cumulative 1+ pack-year smoking history * Have a recent stable forced expiratory volume in one second (FEV1) \<35% predicted * Have contraindications for MRI studies (implanted devices/materials; inability to tolerate; claustrophobia or severe anxiety that would preclude MRI/imaging) * Have had a significant clinical radiation exposure (as determined by the investigator) within the past 6 months. Potential participants who have had a chest CT within the past 6 months may be eligible to be enrolled and their clinical CT will be utilized as the baseline for this study * Are pregnant or breastfeeding * Have any comorbidities likely to impact lung function (e.g., complex congenital heart disease, severe scoliosis, diseases involving immune dysregulation, lung transplantation, lung lobectomy, end-stage renal disease, or poor overall health status).