Clinical Research Directory
Browse clinical research sites, groups, and studies.
Phase III, Open-label, First-line Study of Dato-DXd in Combination With Durvalumab and Carboplatin for Advanced NSCLC Without Actionable Genomic Alterations
Sponsor: AstraZeneca
Summary
This is a Phase III, randomized, open-label, multicenter, global study to compare the efficacy and safety of Datopotamab Deruxtecan (Dato-DXd) in combination with durvalumab and carboplatin compared with pembrolizumab in combination with histology-specific platinum-based chemotherapy as first-line treatment of adults with stage IIIB, IIIC, or IV NSCLC without actionable genomic alterations (including sensitizing EGFR mutations, and ALK and ROS1 rearrangements).
Official title: A Phase III, Randomised, Open-label, Multicentre, Global Study of Datopotamab Deruxtecan (Dato-DXd) in Combination With Durvalumab and Carboplatin Versus Pembrolizumab in Combination With Platinum-based Chemotherapy for the First-line Treatment of Patients With Locally Advanced or Metastatic NSCLC Without Actionable Genomic Alterations (D926NC00001; AVANZAR)
Key Details
Gender
All
Age Range
18 Years - 130 Years
Study Type
INTERVENTIONAL
Enrollment
1350
Start Date
2022-12-29
Completion Date
2027-11-01
Last Updated
2026-03-13
Healthy Volunteers
No
Conditions
Interventions
Datopotamab deruxtecan
Intravenous (IV) infusion every 3 weeks (Q3W) on Day 1 of each 21-day cycle.
Durvalumab
Intravenous (IV) infusion every 3 weeks (Q3W) on Day 1 of each 21-day cycle.
Carboplatin
Intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.
Pembrolizumab
Intravenous (IV) infusion every 3 weeks (Q3W) on Day 1 of each 21-day cycle for a maximum of 35 cycles or 2 years (whichever occurs first).
Cisplatin
Intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.
Pemetrexed
Intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle.
Paclitaxel
Intravenous (IV) infusion every 3 weeks on Day 1 of each 21-day cycle for up to 4 cycles.
Locations (254)
Research Site
Phoenix, Arizona, United States
Research Site
Tucson, Arizona, United States
Research Site
Hot Springs, Arkansas, United States
Research Site
Little Rock, Arkansas, United States
Research Site
Springdale, Arkansas, United States
Research Site
Fountain Valley, California, United States
Research Site
Los Angeles, California, United States
Research Site
Orange, California, United States
Research Site
Boulder, Colorado, United States
Research Site
Fort Myers, Florida, United States
Research Site
Jacksonville, Florida, United States
Research Site
St. Petersburg, Florida, United States
Research Site
West Palm Beach, Florida, United States
Research Site
Hinsdale, Illinois, United States
Research Site
Fort Wayne, Indiana, United States
Research Site
Bettendorf, Iowa, United States
Research Site
Iowa City, Iowa, United States
Research Site
Waukee, Iowa, United States
Research Site
Baton Rouge, Louisiana, United States
Research Site
Covington, Louisiana, United States
Research Site
Duluth, Minnesota, United States
Research Site
Rochester, Minnesota, United States
Research Site
Hannibal, Missouri, United States
Research Site
Lincoln, Nebraska, United States
Research Site
Lincoln, Nebraska, United States
Research Site
Clifton Park, New York, United States
Research Site
Asheville, North Carolina, United States
Research Site
Canton, Ohio, United States
Research Site
Columbus, Ohio, United States
Research Site
Maumee, Ohio, United States
Research Site
Tulsa, Oklahoma, United States
Research Site
Portland, Oregon, United States
Research Site
Salem, Oregon, United States
Research Site
Philadelphia, Pennsylvania, United States
Research Site
Philadelphia, Pennsylvania, United States
Research Site
Philadelphia, Pennsylvania, United States
Research Site
York, Pennsylvania, United States
Research Site
Watertown, South Dakota, United States
Research Site
Memphis, Tennessee, United States
Research Site
Dallas, Texas, United States
Research Site
Fort Worth, Texas, United States
Research Site
Houston, Texas, United States
Research Site
Houston, Texas, United States
Research Site
Irving, Texas, United States
Research Site
Fairfax, Virginia, United States
Research Site
Henrico, Virginia, United States
Research Site
Norfolk, Virginia, United States
Research Site
Renton, Washington, United States
Research Site
Spokane, Washington, United States
Research Site
Tacoma, Washington, United States
Research Site
Appleton, Wisconsin, United States
Research Site
La Crosse, Wisconsin, United States
Research Site
Graz, Austria
Research Site
Rankweil, Austria
Research Site
Vienna, Austria
Research Site
Vienna, Austria
Research Site
Blumenau, Brazil
Research Site
Florianópolis, Brazil
Research Site
Fortaleza, Brazil
Research Site
Londrina, Brazil
Research Site
Porto Alegre, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
São Paulo, Brazil
Research Site
Taubaté, Brazil
Research Site
Vitória, Brazil
Research Site
Sofia, Bulgaria
Research Site
Sofia, Bulgaria
Research Site
Varna, Bulgaria
Research Site
Saint John, New Brunswick, Canada
Research Site
Brampton, Ontario, Canada
Research Site
Greater Sudbury, Ontario, Canada
Research Site
Kitchener, Ontario, Canada
Research Site
Newmarket, Ontario, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Montreal, Quebec, Canada
Research Site
Saint-Jérôme, Quebec, Canada
Research Site
Saskatoon, Saskatchewan, Canada
Research Site
Beijing, China
Research Site
Beijing, China
Research Site
Beijing, China
Research Site
Beijing, China
Research Site
Beijing, China
Research Site
Beijing, China
Research Site
Changsha, China
Research Site
Changsha, China
Research Site
Chengdu, China
Research Site
Chengdu, China
Research Site
Chongqing, China
Research Site
Guangzhou, China
Research Site
Guangzhou, China
Research Site
Hefei, China
Research Site
Jinan, China
Research Site
Kunming, China
Research Site
Lanzhou, China
Research Site
Liuchow, China
Research Site
Shandong, China
Research Site
Shanghai, China
Research Site
Shanghai, China
Research Site
Shanghai, China
Research Site
Shantou, China
Research Site
Shenyang, China
Research Site
Shenzhen, China
Research Site
Taiyuan, China
Research Site
Tianjin, China
Research Site
Wenzhou, China
Research Site
Wuhan, China
Research Site
Wuhan, China
Research Site
Xiamen, China
Research Site
Yangzhou, China
Research Site
Zhengzhou, China
Research Site
Brest, France
Research Site
Créteil, France
Research Site
Gleizé, France
Research Site
Montpellier, France
Research Site
Nîmes, France
Research Site
Paris, France
Research Site
Paris, France
Research Site
Rouen, France
Research Site
Saint-Quentin, France
Research Site
Strasbourg, France
Research Site
Toulon, France
Research Site
Toulouse, France
Research Site
Tours, France
Research Site
Bad Berka, Germany
Research Site
Berlin, Germany
Research Site
Frankfurt A. Main, Germany
Research Site
Gauting, Germany
Research Site
Gütersloh, Germany
Research Site
Hamburg, Germany
Research Site
Kassel, Germany
Research Site
Kiel, Germany
Research Site
Koblenz, Germany
Research Site
Minden, Germany
Research Site
Rosenheim, Germany
Research Site
Velbert, Germany
Research Site
Würzburg, Germany
Research Site
Athens, Greece
Research Site
Athens, Greece
Research Site
Athens, Greece
Research Site
Piraeus, Greece
Research Site
Thessaloniki, Greece
Research Site
Thessaloniki, Greece
Research Site
Budapest, Hungary
Research Site
Budapest, Hungary
Research Site
Gyöngyös - Mátraháza, Hungary
Research Site
Kaposvár, Hungary
Research Site
Pécs, Hungary
Research Site
Szekszárd, Hungary
Research Site
Szolnok, Hungary
Research Site
Törökbálint, Hungary
Research Site
Calicut, India
Research Site
Delhi, India
Research Site
Delhi, India
Research Site
Jaipur, India
Research Site
Kolkata, India
Research Site
Madurai, India
Research Site
Puducherry, India
Research Site
Florence, Italy
Research Site
Lecco, Italy
Research Site
Messina, Italy
Research Site
Naples, Italy
Research Site
Orbassano, Italy
Research Site
Padova, Italy
Research Site
Parma, Italy
Research Site
Peschiera del Garda, Italy
Research Site
Rozzano, Italy
Research Site
Bunkyō City, Japan
Research Site
Chūōku, Japan
Research Site
Hamamatsu, Japan
Research Site
Hamamatsu, Japan
Research Site
Hidaka-shi, Japan
Research Site
Hirosaki-shi, Japan
Research Site
Hiroshima, Japan
Research Site
Kumamoto, Japan
Research Site
Nagoya, Japan
Research Site
Nagoya, Japan
Research Site
Okayama, Japan
Research Site
Osaka, Japan
Research Site
Osakasayama-shi, Japan
Research Site
Sapporo, Japan
Research Site
Sunto-gun, Japan
Research Site
Wakayama, Japan
Research Site
Yokohama, Japan
Research Site
Yokohama, Japan
Research Site
Del. Cuauhtemoc, Mexico
Research Site
Mexico City, Mexico
Research Site
México, Mexico
Research Site
San Luis Potosí City, Mexico
Research Site
Arequipa, Peru
Research Site
Concepción, Peru
Research Site
Lima, Peru
Research Site
Lima, Peru
Research Site
Lima, Peru
Research Site
Lima, Peru
Research Site
Bydgoszcz, Poland
Research Site
Bystra, Poland
Research Site
Grudziądz, Poland
Research Site
Kielce, Poland
Research Site
Koszalin, Poland
Research Site
Olsztyn, Poland
Research Site
Poznan, Poland
Research Site
Przemyśl, Poland
Research Site
Racibórz, Poland
Research Site
Radom, Poland
Research Site
Siedlce, Poland
Research Site
Busan, South Korea
Research Site
Cheongju-si, South Korea
Research Site
Jinju, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Seoul, South Korea
Research Site
Suwon, South Korea
Research Site
Suwon, South Korea
Research Site
Las Palmas de Gran Canaria, Spain
Research Site
Lugo, Spain
Research Site
Madrid, Spain
Research Site
Santander, Spain
Research Site
Seville, Spain
Research Site
Valencia, Spain
Research Site
Zaragoza, Spain
Research Site
Gävle, Sweden
Research Site
Linköping, Sweden
Research Site
Lund, Sweden
Research Site
Stockholm, Sweden
Research Site
Uppsala, Sweden
Research Site
Hsinchu, Taiwan
Research Site
New Taipei City, Taiwan
Research Site
Taichung, Taiwan
Research Site
Tainan, Taiwan
Research Site
Taipei, Taiwan
Research Site
Taoyuan District, Taiwan
Research Site
Adana, Turkey (Türkiye)
Research Site
Ankara, Turkey (Türkiye)
Research Site
Edirne, Turkey (Türkiye)
Research Site
Istanbul, Turkey (Türkiye)
Research Site
Izmir, Turkey (Türkiye)
Research Site
Aberdeen, United Kingdom
Research Site
Cambridge, United Kingdom
Research Site
Cardiff, United Kingdom
Research Site
Cheltenham, United Kingdom
Research Site
Edinburgh, United Kingdom
Research Site
London, United Kingdom
Research Site
London, United Kingdom
Research Site
Manchester, United Kingdom
Research Site
Middlesbrough, United Kingdom
Research Site
Newcastle upon Tyne, United Kingdom
Research Site
Taunton, United Kingdom
Research Site
Hanoi, Vietnam
Research Site
Ho Chi Minh City, Vietnam