Clinical Research Directory

Inclusion Criteria: * Be admitted to a participating hospital at the time of randomization * Be 18 years of age or older * Currently be experiencing a severe injection-related infection/SIRI or suspected SIRI * Have an indication of injecting drugs in the prior year * Provide informed consent * Ability to communicate in English * Provide sufficient locator information * Sign a HIPAA form and/or EHR release to facilitate record abstraction * Report being willing to return for follow-up visits Exclusion Criteria: All individuals meeting any of the exclusion criteria will be excluded from study participation. Specifically, individuals will be excluded from participation if they: * have significant cognitive or developmental impairment to the extent that they are unable to provide informed consent * (or their legal guardian/representative) are unable or unwilling to give written informed consent * are currently in jail, prison or other overnight facility as required by court of law or have pending legal action that could prevent participation in study activities * are terminated via site principal investigator decision with agreement from one of the study lead investigators.