Clinical Research Directory

Inclusion Criteria: * Age from 18 to 75 years old, * Acute pancreatitis according to the Atlanta classification of OP (2012), without signs of infection, * Acute pancreatitis confirmed by tomography. Score according to the Modified CTSI Pancreatitis Severity Index: from 4 points and above, * No more than 3 days from the onset of an attack of acute pancreatitis, * APACHE II score - at least 10, * The patient must receive adequate fluid therapy (at least 30 ml/kg) from the time of randomization until the first therapy, * The patient's condition allows therapy for at least 4 hours. Exclusion Criteria: * Age over 75, * More than 3 days from the onset of an attack of acute pancreatitis, * An attack of acute pancreatitis, as an exacerbation of chronic pancreatitis. * Acute pancreatitis as a complication of a surgical operation, * DS - Septic shock (Sepsis-3, 2016) * The presence of a focus of non-sanitized surgical infection, * Charlson comorbidity index\> 5 points, * Critical hypoxemia (PaO2/FiO2 \< 150 mm Hg), * GCS level of consciousness \< 12 points, * Obesity 3 degrees and above (weight over 150 kg), * Blood triglyceride level \>1000 mg/dl, (11.2 mmol/l), * Dementia, * Inability to achieve or maintain min SBP ≥ 65 mm Hg. Art., despite vasopressor therapy and infusion therapy in tech. 24 hours * Presence of end-stage renal disease requiring RRT, * The presence of cirrhosis of the liver (\> 5 points according to the Child-Pugh classification), * Unresolved biliary hypertension syndrome, * Acute thromboembolism of the pulmonary artery, confirmed by tomography, * Acute myocardial infarction within the last 4 weeks, * Acute cerebrovascular accident, * Transfusion reaction, * Severe congestive heart failure, * Uncontrolled bleeding (acute blood loss in the last 24 hours).