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Barotrauma in Hyperbaric Oxygen Therapy
Sponsor: John Muir Health
Summary
The purpose of this research is to study whether the use of pseudoephedrine can help prevent middle ear trauma during HBOT. Pseudoephedrine is an approved drug that is used for temporary relief of nasal or sinus pain and pressure.
Official title: Pseudoephedrine Prophylaxis for Prevention of Middle Ear Barotrauma in Hyperbaric Oxygen Therapy
Key Details
Gender
All
Age Range
18 Years - Any
Study Type
INTERVENTIONAL
Enrollment
90
Start Date
2023-01-31
Completion Date
2026-07
Last Updated
2025-08-27
Healthy Volunteers
No
Conditions
Interventions
Pseudoephedrine Pill
One-time 60mg dose given orally between 45-120 minutes prior to hyperbaric oxygen therapy
Placebo
One time dose given orally between 45-120 minutes prior to hyperbaric oxygen therapy
Locations (1)
John Muir Health
Walnut Creek, California, United States