Clinical Research Directory

Inclusion Criteria: 1. Gender is not limited, age 18-75 years old; 2. Estimated survival is greater than 3 months; 3. Newly diagnosed patients with head and neck cancer without any treatment, or patients with refractory recurrent advanced head and neck cancer for which there is no available effective treatment; 4. Patients with head and neck cancer whose tumor tissue can be surgically harvested; 5. Volunteer to join the study and sign the informed consent. Exclusion Criteria: 1. Infected or had been infected with COVID-19; 2. Active hepatitis B or C virus, HIV infection, or other uncured active infected persons; 3. Patients with head and neck cancer who had received the following treatments: The patient had a history of using PD-1 and other immune checkpoint inhibitors 8 weeks before surgery; History of chemotherapy drug use 8 weeks before surgery; A history of hormone drug use within 4 weeks before surgery; 4. Other situations that are not appropriate to be included in the clinical trial.