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A Collaborative Resource of Heidelberg Multimodal Imaging of Intermediate and Early Atrophic AMD Cases to Study Prediction of Disease Progression
Sponsor: Association for Innovation and Biomedical Research on Light and Image
Summary
This is a multicentre retrospective and prospective cohort study with the goal to develop a well-characterised multimodal image database of eyes with intermediate AMD with and without early atrophy. The main objectives are: 1. Develop a collaborative well-characterised database on intermediate AMD with or without early atrophy. 2. Grading of these images to explore imaging markers of progression. 3. Develop predictive models as a secondary analysis of our dataset. This study will recruit around 1.000 eyes in 6 months. All consenting patients who have had at least 3 clinic visits with multimodal imaging done at least at 6 months interval between 2 visits and meet the inclusion and exclusion criteria will be included in the study for retrospective data collection. Those with one visit remaining to complete 2 years, images will be acquired prospectively. In addition to the images, routine demographic data (age and sex) and available visual acuity (VA) (BCVA if possible, VA with Pinhole or VA with patient's glasses) will be collected. Multimodal imaging includes mandated macular OCT with or without enhanced depth imaging and infrared imaging. Fundus autofluorescence (AF) and multicolor imaging are optional. All imaging must be done on Heidelberg Spectralis system.
Official title: A Collaborative Resource of Heidelberg Multimodal Imaging of Intermediate and Early Atrophic AMD Cases to Study Prediction of Disease Progression: (INTERCEPT-AMD)
Key Details
Gender
All
Age Range
Any - Any
Study Type
OBSERVATIONAL
Enrollment
1000
Start Date
2023-05-04
Completion Date
2025-12-31
Last Updated
2025-09-30
Healthy Volunteers
No
Interventions
Collection of both retrospective and prospective data collection in 3 visits.
3 clinic visits with multimodal imaging done at least at 6 months interval between 2 visits and meet the inclusion and exclusion criteria. Those with one visit remaining to complete 2 years, images will be acquired prospectively. In addition to the images, routine demographic data (age and sex) and available visual acuity (VA) (BCVA if possible, VA with Pinhole or VA with patient's glasses) will be collected. Multimodal imaging includes mandated macular OCT with or without enhanced depth imaging and infrared imaging. Fundus autofluorescence (AF) and multicolor imaging are optional. All imaging must be done on Heidelberg Spectralis system.
Locations (25)
Department of Ophthalmology, University Hospital, Nantes
Nantes, France
Department of Ophthalmology University of Bonn
Bonn, Germany
Department of Ophthalmology University of Freiburg
Freiburg im Breisgau, Germany
Department of Ophthalmology Justus/Liebig/University/Giessen
Giesen, Germany
Department of Ophthalmology St. Franziskus/Hospital Münster
Münster, Germany
Department of Ophthalmology University of Muenster Medical Center
Münster, Germany
Eye Clinic Sulzbach, Knappschaft Hospital Saar
Sulzbach, Germany
Royal Victoria Eye and Ear Research Foundation
Dublin, Ireland
Medical Retina Service, Operative Unit Ophthalmology / MultiMedica Spa (IRCCSMM)
Milan, Italy
Eye Unit, University Hospital Maggiore della Carità
Novara, Italy
Department of Ophthalmology University of Udine
Udine, Italy
Department of Ophthalmology Radboud University Medical Centre Nijmegen
Nijmegen, Netherlands
AIBILI-CEC (AIBILI- Clinical Trials Centre)
Coimbra, Portugal
Espaço Médico de Coimbra
Coimbra, Portugal
Instituto de Oftalmologia Dr. Gama Pinto
Lisbon, Portugal
Department of Ophthalmology Porto Medical School / Hospital S. João
Porto, Portugal
Institut Català de Retina (ICR), Clinical Trial Unit
Barcelona, Spain
Institut de la Màcula Centro Médico Teknon
Barcelona, Spain
Valles Ophthalmology Research, S.L.
Barcelona, Spain
Clínica Oftalmológica AIKEN / Fundación Aiken de la Comunitat Valenciana
Valencia, Spain
University Hospital Basel, University Eye Clinic, Basel
Basel, Switzerland
Swiss Visio Retina Research Center, Swiss Visio Montchoisi
Lausanne, Switzerland
Clinical Trial Unit, Dep. Ophth., Gloucestershire Hospitals NHS Foundation Trust
Cheltenham, United Kingdom
Clinical Eye Research Centre - St. Paul's Eye Unit, Royal Liverpool University Hospital
Liverpool, United Kingdom
NIHR Moorfields Clinical Research Facility, Moorfields Eye Hospital, NHS Foundation Trust
London, United Kingdom